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Enzyme List for pathway PLCbeta (Pathway Number 112)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
PLC

Enzyme Molecule:
PLC		19.99942.54explicit E-S complexPIP2
DAG
IP3(145)
  Smrcka et al; Science 251, 15.2.1991, pp804-807
2 Enzyme Activity:
PLC-Ca

Enzyme Molecule:
PLC-Ca		19.8408104explicit E-S complexPIP2
DAG
IP3(145)
  From Sternweis et al Phil Trans R Soc Lond 1992, also matched by Homma et al. k1 = 1.5e-5, now 4.2e-6 k2 = 70/sec; now 40/sec k3 = 17.5/sec; now 10/sec Note that the wording in Sternweis et al is ambiguous re the Km. Also Smrcka et al; Science 251, 15.2.1991, pp804-807
3 Enzyme Activity:
PLC-Gq

Enzyme Molecule:
PLC-Gq		5754explicit E-S complexPIP2
DAG
IP3(145)
  from Smrcka et al, 1991 Science 251: 804-807
4 Enzyme Activity:
PLCb-Ca-Gq

Enzyme Molecule:
PLC-Ca-Gq		4.99991604explicit E-S complexPIP2
DAG
IP3(145)
  Km: Sternweis et al, Phil Trans R Soc Lond 1992 Vmax: Smrcka et al, Science 1991
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