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Enzyme List for pathway CaMKII (Pathway Number 174)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
phosph_T286

Enzyme Molecule:
Tot-active-CaMKI
I		0.2547100explicit E-S complexCaMKII-CaMCa4
Trapped-T286
  This enzyme represents an intra-holoenzyme reaction from one active subunit to its neighbor. k1 is now in units of 1/sec. The Km, Ratio and Vmax terms are pretty meaningless. The enzyme really is there just to represent the forward rate of 0.5 from CaMKII-CaMCa4 to Trapped-T285. We have a high k3 so that the reac is limited only by k1. The enzyme itself does not have much purpose other than to allow scaling of the overall rate by the proportion of adjacent molecules in the appropriate state.
2 Enzyme Activity:
phosph_T305

Enzyme Molecule:
Tot-active-CaMKI
I		1.2733100explicit E-S complexAutonomous
Capped
  This enzyme also represents an intra-holoenzyme reaction. So it is not really treated as an enzyme in Holme's model, more like a probability of reaction that scales according to the number of active CaMKII neighboring subunits. Here we approximate it as an enzyme rate limited by the k1=0.1 step, no back reaction, and with a scaling from Total_CaMKII such that the effective forward rate will simply be the fraction of CaMKII that are active, times 1/10 for nearest neigbors, times k1.
Pathway DetailMolecule ListEnzyme ListReaction List