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Enzyme List for pathway Shared_Object_AMPAR_traff_model0 (Pathway Number 234)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
phosph-AC2

Enzyme Molecule:
PKC-active		33.333744explicit E-S complexAC2
AC2*
  Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
2 Enzyme Activity:
PKC-phosph-neuro
granin

Enzyme Molecule:
PKC-active		28.62730.584.03448explicit E-S complexneurogranin
neurogranin*
  Rates from Huang et al ABB 305:2 570-580 1993
3 Enzyme Activity:

PKC-phosph-neuro
granin_
PSD

Enzyme Molecule:
PKC-active		28.62730.584.03448explicit E-S complexneurogranin_PSD
  • neurogranin*_
    PSD
    •   Rates from Huang et al ABB 305:2 570-580 1993
    4 Enzyme Activity:
    PKC-phosph-ng-Ca
    M

    Enzyme Molecule:
    PKC-active    		28.59560.354explicit E-S complexneurogranin-CaM
    		CaM
    neurogranin*
      Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
    5 Enzyme Activity:

    PKC-phosph-ng-Ca
    M_
    PSD

    Enzyme Molecule:
    PKC-active    		28.59560.354explicit E-S complex

  • neurogranin-CaM_
    PSD
    		• CaM-PSD
  • neurogranin*_
    PSD
    •   Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
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