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Enzyme List for pathway NOS (Pathway Number 90) | | Molecule Name/
Site Name | Km (uM) | kcat (1/s) | Ratio
(k2/k3) | Enzyme Type | Substrate | Product |
| 1 |
Enzyme Activity:
kenz
Enzyme Molecule:
Ca-CaMnNOS | 10 | 16.667 | 4 | explicit E-S complex | Larg
| NO
cit
| | | Km for purified NOS is estimated between 1 - 10 uM. (Prog in Neurobiology, 2001, 64: 365-391) Vmax for unphosporylated NOS, the active form, is 500-1500 nmol/nmol/min (Montellano et al., 1998, JBC,26(12): 1185-1189). Hayashi et al., JBC, 1999, 274(29):20597-20602 report Vmax (nmol/min/mg) of nNOS Unphosporylated at 95.7 (+-) 4.2 |
| 2 |
Enzyme Activity:
kenz
Enzyme Molecule:
CaMKIV | 5 | 18 | 4 | explicit E-S complex | nNOS
| NOS*
| | | Hayashi et al., 1999, JBC,274(29):20597-20602. and other reported data from different sources. |
| 3 |
Enzyme Activity:
kenz
Enzyme Molecule:
CaMKIIalpha | 5 | 28.5 | 4 | explicit E-S complex | nNOS
| NOS*
| | | Hayashi et al., 1999, JBC,274(29):20597-20602. and from various other literature datas. |
| 4 |
Enzyme Activity:
kenz
Enzyme Molecule:
CaMKIalpha | 5 | 17 | 4 | explicit E-S complex | nNOS
| NOS*
| | | enzyme parameters used from different literature. Hayashi et al., 1999, JBC,274(29):20597-20602. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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