 |  |  EGFR |
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Molecule List for pathway Shared_Object_EGFR_MAPK (Pathway Number 229) | | Name | Initial Conc. (uM) | Volume (fL) | Buffered | | 1 | BetaGamma | 0.0094 | 1000 | Yes | | | These exist in a nebulous sense in this model, basically only to balance the conservation equations. The details of their reassociation with G-GDP are not modeled Resting level =0.0094, stim level =.0236 from all42.g ish. | | 2 | CaM-Ca4 | 0 | 1000 | Yes | | | Resting level is ~1e-5 uM, small enough to ignore. | | 3 | MAPK* | 0 | 1000 | No | | | | | 4 | MKP-1 | 0.0024 | 1000 | No | | | MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 487-493 1993. Levels of MKP-1 are regulated, and rise in 1 hour. Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134 is 40 min. 80% deph of MAPK in 20 min Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches from jun96 on. | | 5 | PKA-active | 0.015 | 1000 | Yes | | | | | 6 | PKC-active | 0.09 | 1000 | Yes | | | | | 7 | PPhosphatase2A | 0.224 | 1000 | No | | | Refs: Pato et al Biochem J 293:35-41(93); Takai&Mieskes Biochem J 275:233-239 k1=1.46e-4, k2=1000,k3=250. these use kcat values for calponin. Also, units of kcat may be in min! revert to Vmax base: k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6 CoInit assumed 0.1 uM. See NOTES for MAPK_Ras50.g. CoInit now 0.08 Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm searches from jun 96 on. | | 8 | Shc*.Sos.Grb2 | 0 | 1000 | No | | | |
Pathway Details Molecule List Enzyme List Reaction List
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