| | Name | Initial Conc. (uM) | Volume (fL) | Buffered |
| 1 | GDP.Ran-cytoplasmic | 5 | 18000 | No |
| | cytoplasmic-GDP.Ran Cytoplasmic fraction of GDP bound Ran Cytoplasmic volume = 1.8 pL = 1.8e-15 m^3 Initial cytoplasmic GDP.Ran concentration = 5 uM Table II footnote Gorlich D et al (2003) EMBO J 22(5):1088-1100 |
| 2 | GTP.Ran-cytoplasmic | 0 | 18000 | No |
| | cytoplasmic-GTP.Ran Cytoplasmic fraction of Ran-GTP complex Cytoplasmic volume = 1.8 pL = 1.8e-16m^3 Gorlich D et al (2003) EMBO J 22(5):1088-1100 |
| 3 | NTF2 | 0.3 | 18000 | Yes |
| | NTF2: Nuclear Transport Factor 2 dimers Cytoplasmic volume = 1.8 pL = 1.8e-15 m^3 Total cellular concentration of NTF2 dimers = 0.3 uM Table II footnote Gorlich D et al (2003) EMBO J 22(5):1088-1100 Since it is the total cellular conc. the pool is buffered |
| 4 | NTF2-GDP.Ran | 0 | 18000 | No |
| | NTF2-GDP.Ran Cytoplasmic fraction of GDP bound Ran complexed with NTF2 Nuclear volume = 1.2 pL = 1.2e-15 m^3 Footnote for Table 2 Gorlich D et al (2003) EMBO J 22(5):1088-1100 Initial cytoplasmic GDP.Ran concentration = 5 uM Table II footnote |
| 5 | RanBP1 | 2 | 18000 | No |
| | RanBP1 RanBP1 in the cytoplasm Cytoplasmic volume = 1.8 pL = 1.8e-15 m^3 Total cytoplasmic concentration of RanBP1 = 2 uM Supplementary Table B Gorlich D et al (2003) EMBO J 22(5):1088-1100 |
| 6 | RanBP1.RanGTP | 0 | 18000 | No |
| | RanBP1.RanGTP Cytoplasmic volume = 1.8 pL = 1.8e-15 m^3 Gorlich D et al (2003) EMBO J 22(5):1088-1100 |
| 7 | RanGAP | 0.7 | 18000 | No |
| | RanGAP: RanGAP in the cytoplasm Ran has very low intrinsic GTPase activity and is stimulated by the Ran GTPase activator RanGAP. This has an antagonistic regulator to RCC1, converting Ran into its GDP bound OFF form. F. Ralf Bischoff et al (1994) PNAS, USA 91:2587-2591 Cytoplasmic volume = 1.8 pL = 1.8e-15 m^3 Total cytoplasmic concentration of RanGAP = 0.7 uM Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100 |
