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Molecule List for pathway CaM (Pathway Number 358) | | Name | Initial Conc. (uM) | Volume (fL) | Buffered | | 1 | CaM | 20 | 1.5 | No | | | There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels. | | 2 | neurogranin | 10 | 1.5 | No | | | Also known as RC3 and p17 and BICKS. Conc in brain >> 2 uM from Martzen and Slemmon J neurosci 64 92-100 1995 but others say less without any #s. Conc in dend spines is much higher than overall, so it could be anywhere from 2 uM to 50. We will estimate 10 uM as a starting point. Gerendasy et al JBC 269:35 22420-22426 1994 have a skeleton model (no numbers) indicating CaM-Ca(n) binding .... | | 3 | neurogranin* | 0 | 1.5 | No | | | The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993) | | 4 | neurogranin-CaM | 0 | 1.5 | No |
Pathway Details Molecule List Enzyme List Reaction List
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