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Molecule List for pathway NOS (Pathway Number 65) | | Name | Initial Conc. (uM) | Volume (fL) | Buffered | | 1 | Ca-CaM_nNOS | 0 | 0.0016667 | No | | | The CaM-Ca bound nNOS, which is the acitve form. | | 2 | CaM-Ca4 | 0 | 0.0016667 | No | | | | | 3 | Cit | 0 | 0.0016667 | No | | | | | 4 | L-Arg | 100 | 0.0016667 | No | | | The intracellular concentrations are atleast 100 uM. Substrate for nNOS. | | 5 | nNOS | 0.5 | 0.0016667 | No | | | Neuronal Nitric Oxide Synthase. Found in the neurons, activity is dependent on CaM binding, in response to Ca levels. Molecular weight ~160 kDa. | | 6 | nNOS.arg | 0 | 0.0016667 | No | | | Arginine binds to NOS first before the synthesis of NO from L-Arginine. | | 7 | nNOS.Cit+NO | 0 | 0.0016667 | No | | | Citrulline and NO basically dissociate from the NOS enzyme complex, and this is the NOS bound with Citrulline and NO, and they dissociate in the subsequent step. | | 8 | nNOS.OH.Arg | 0 | 0.0016667 | No | | | This is the intermediate formed during the catalytic activity of NOS in synthesising NO, N-hydroxy arginine. | | 9 | NO | 0 | 0.0016667 | No | | | Endogenously produced NO concentrations in the course of signal transduction processes are < 100 nM. (Varner et al., Nitric oxide in the nervous system, Academic press, London, UK, pp.191-206.) | | 10 | OH.Arg | 0 | 0.0016667 | No | | | |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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