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Parameters for EGFR (Pathway Number 223)

Pathway Layout

Pathway Basic Parameters

Pathway NameEGFR
Pathway Entry Number 223
Accession Number 52
Accession Name EGFR_Signaling_pathway
Species Harlan Sprague Dawley rat; mammalian
Tissue Hepatocytes
CellCompartmentCell membrane + cytosol
Related Pathways 8, 77, 213, 232, 319, 336, 354
Notes  This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999.
Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421.

Statistics

33
3
22

Conversion format

This pathway is part of accession 52 and is completely specified in the file acc52.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc52.g   
GENESIS Format (Annotated version)    Anno_acc52.g   
SBML format    acc52.xml   
Pathway DetailMolecule ListEnzyme ListReaction List