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Accession Type:
Pathway

EGFR_Signaling_
pathway

		EGFR
		Molecule
		Enzyme
		Reaction

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Reaction List for pathway EGFR (Pathway Number 223)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.

	Name	Kf	Kb	Kd	tau	Substrate	Product
1	r1	kf (uM^-1 s^-1)	0.06 (s^-1)	Kd(bf) = 0.02(uM)	-	EGF R	Ra
	Taken from Kholodenko et al 1999.
2	r10	kf (uM^-1 s^-1)	0.06 (s^-1)	Kd(bf) = 6(uM)	-	R-G SOS	R-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
3	r11	kf (s^-1)	4.5 (uM^-1 s^-1)	Kd(cb) = 150(uM)	-	R-G-S	G-S RP
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
4	r12	kf (s^-1)	0.1 (uM^-1 s^-1)	Kd(cb) = 66.6667(uM)	-	G-S	Grb SOS
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
5	r13	kf (uM^-1 s^-1)	0.6 (s^-1)	Kd(bf) = 0.0067(uM)	-	RP Shc	R-Sh
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
6	r14	kf (s^-1)	0.06 (s^-1)	Keq = 0.01(uM)	0.165sec	R-Sh	R-ShP
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
7	r15	kf (s^-1)	0.9 (uM^-1 s^-1)	Kd(cb) = 3(uM)	-	R-ShP	ShP RP
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
8	r17	kf (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0333(uM)	-	R-ShP Grb	R-Sh-G
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
9	r18	kf (s^-1)	0.9 (uM^-1 s^-1)	Kd(cb) = 3(uM)	-	R-Sh-G	Sh-G RP
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
10	r19	kf (uM^-1 s^-1)	0.0214 (s^-1)	Kd(bf) = 0.0021(uM)	-	R-Sh-G SOS	R-Sh-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
11	r2	kf (uM^-1 s^-1)	0.1 (s^-1)	Keq = 0.01(uM)	-	Ra Ra	R2
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
12	r20	kf (s^-1)	0.24 (uM^-1 s^-1)	Kd(cb) = 2(uM)	-	R-Sh-G-S	Sh-G-S RP
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
13	r21	kf (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0333(uM)	-	ShP Grb	Sh-G
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
14	r22	kf (uM^-1 s^-1)	0.064 (s^-1)	Kd(bf) = 0.0021(uM)	-	Sh-G SOS	Sh-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
15	r23	kf (s^-1)	21 (uM^-1 s^-1)	Kd(cb) = 210(uM)	-	Sh-G-S	G-S ShP
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
16	r24	kf (uM^-1 s^-1)	0.0429 (s^-1)	Kd(bf) = 0.0048(uM)	-	R-ShP G-S	R-Sh-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
17	r25	kf (s^-1)	0.03 (s^-1)	Keq = 0.03(uM)	0.971sec	PLCrP	PLCr-I
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
18	r3	kf (s^-1)	0.01 (s^-1)	Keq = 0.01(uM)	0.99sec	R2	RP
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
19	r5	kf (uM^-1 s^-1)	0.2 (s^-1)	Kd(bf) = 0.0033(uM)	-	RP PLCr	R-PL
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
20	r6	kf (s^-1)	0.05 (s^-1)	Keq = 0.05(uM)	0.952sec	R-PL	R-PLP
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
21	r7	kf (s^-1)	6 (uM^-1 s^-1)	Kd(cb) = 20(uM)	-	R-PLP	PLCrP RP
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
22	r9	kf (uM^-1 s^-1)	0.05 (s^-1)	Kd(bf) = 0.0167(uM)	-	RP Grb	R-G
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.

Pathway Details Molecule List Enzyme List Reaction List

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