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Accession Type:
Pathway
MAPK_osc
MAPK
 Molecule
 Enzyme
 Reaction

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Reaction List for pathway MAPK (Pathway Number 139)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 Neg_feedback1
(uM^-1 s^-1)
0.009
(s^-1)
Kd(bf) = 0.009(uM)-MAPK-PP
Ras-MKKKK
  • inactiveRas-MKKK
  •   From Kholodenko, 2000 Eur J Biochem 267 the Kd is 9 nM. We use a rather fast Kf of 1/sec/uM so that equilibrium is maintained.


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