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Accession Type:
Network

Osc_Ca_
IP3metabolism

		CaRegulation
		Molecule
		Enzyme
		Reaction

Othmer-Tang-mode
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Reaction List for pathway CaRegulation (Pathway Number 170)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.

	Name	Kf	Kb	Kd	tau	Substrate	Product
1	Ca10-bind-Cal	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Ca5-Cal Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester	Ca10-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca5-Cal. Due to system limitations only four are entered.
2	Ca15-bind-Cal	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Ca10-Cal Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester	Ca15-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca10-Cal. Due to system limitations only four are entered.
3	Ca20-bind-Cal	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Ca15-Cal Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester	Ca20-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca15-Cal. Due to system limitations only four are entered.
4	Ca25-bind-Cal	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca20-Cal	Ca25-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca20-Cal. Due to system limitations only four are entered.
5	Ca30-bind-Cal	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Ca25-Cal Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester	Ca30-Calseq
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca25-Cal. Due to system limitations only four are entered.
6	Ca35-bind-Cal	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca30-Calseq	Ca35-Calseq
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca30-Cal. Due to system limitations only four are entered.
7	Ca40-bind-Cal	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca35-Calseq	Ca40-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca35-Cal. Due to system limitations only four are entered.
8	Ca5-bind-Cal	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Calseq Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester	Ca5-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with one Calseq. Due to system limitations only four are entered.
9	inactivate_cap_ Ca	0 (#^-2 s^-1)	10 (s^-1)	Not applicable**	-	Ca-sequester Ca-sequester capacitive_Ca_ entry*	inact_cap_entry
	For non-oscillatory Ca dynamics Kd was set at 3 uM. This did not allow for Ca oscillations characteristic of the Othmer-Tang model. The rates here are constrained solely by the need to generate Othmer-Tang type Ca oscillations.

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration.

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Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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