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Reaction List for pathway MAPK_Asthagiri_enz_fb (Pathway Number 194) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
A1-bind-A2 | 5.0001
(uM^-1 s^-1) | 0.5
(s^-1) | Kd(bf) = 0.1(uM) | - | A2
A1
| A1A2
| | | Kc12 and Kd12 are 3*10^8 M-1 min-1 and 0.5/sec from Asthagiri and Lauffenburger 2001. | | 2 |
C*-bind-A1 | 5.0001
(uM^-1 s^-1) | 0.5
(s^-1) | Kd(bf) = 0.1(uM) | - | C*
A1
| C*A1
| | | Kf1 is 3*10^8 M-1 min-1 and Kr1 is 0.5/sec from Asthagiri and Lauffenburger 2001 | | 3 |
C*-bind-A1A2 | 5.0001
(uM^-1 s^-1) | 0.5
(s^-1) | Kd(bf) = 0.1(uM) | - | A1A2
C*
| E0*
| | | Kf12 and Kr12 are 3*10^8 M-1 min-1 and 0.5/sec from Asthagiri and Lauffenburger 2001. | | 4 |
C*A1-bind-A2 | 5.0001
(uM^-1 s^-1) | 0.5
(s^-1) | Kd(bf) = 0.1(uM) | - | C*A1
A2
| E0*
| | | kf2 and kr2 are 3*10^8 M-1 min-1 and 0.5/sec from Asthagiri and Lauffenburger , 20001. | | 5 |
C-dimer | 1
(uM^-1 s^-1) | 1
(s^-1) | Keq = 1(uM) | - | C
C
| C2
| | | Kc is 6*10^7 M-1 min-1 and Ku is 60 min-1 from Asthagiri, A.R and Lauffenburger, D.A Biotechnol. Prog. 2001, 17, 227-239. | | 6 |
C2-phos | 0.833
(s^-1) | 0.0833
(s^-1) | Keq = 0.1(uM) | 1.091sec | C2
| C*
| | | Kc+ is 50min-1 and Kc- is 5min-1 from Asthagiri and Lauffenburger 2001. | | 7 |
L-bind-R | 0.1666
(uM^-1 s^-1) | 0.005
(s^-1) | Kd(bf) = 0.03(uM) | - | L
R
| C
| | | Kf = 10^7/M-1 min-1 and Kr is 0.3 min-1 from Asthagiri, A.R and Lauffenburger, D.A Biotechnol. Prog. 2001, 17, 227-239. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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