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Accession Type:
Network
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Shared_Object_
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PKC
PLA2
 Molecule
 Enzyme
 Reaction
PLCbeta
Gq
MAPK
Ras
CaMKII
CaM
PP1
PP2B
PKA
AC

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Reaction List for pathway PLA2 (Pathway Number 21)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 DAG-Ca-PLA2-act0.003
(uM^-1 s^-1)		4
(s^-1)		Kd(bf) = 1333.3333(uM)-DAG
PLA2-Ca*
DAG-Ca-PLA2*
2 Degrade-AA0.4
(s^-1)		0
(s^-1)		--AA
APC
3 dephosphorylate-
PLA2*		0.17
(s^-1)		0
(s^-1)		--PLA2*
PLA2-cytosolic
4 PIP2-Ca-PLA2-act0.012
(uM^-1 s^-1)		0.1
(s^-1)		Kd(bf) = 8.3333(uM)-temp-PIP2
PLA2-Ca*
PIP2-Ca-PLA2*
5 PIP2-PLA2-act0.0012
(uM^-1 s^-1)		0.5
(s^-1)		Kd(bf) = 416.6667(uM)-temp-PIP2
PLA2-cytosolic
PIP2-PLA2*
6 PLA2*-Ca-act6
(uM^-1 s^-1)		0.1
(s^-1)		Kd(bf) = 0.0167(uM)-PLA2*
Ca
PLA2*-Ca
7 PLA2-Ca-act1
(uM^-1 s^-1)		0.1
(s^-1)		Kd(bf) = 0.1(uM)-PLA2-cytosolic
Ca
PLA2-Ca*


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Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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