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Reaction List for pathway NOHArginine (Pathway Number 311) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
Imidazole_
release | 57
(s^-1) | 0.07
(uM^-1 s^-1) | Kd(cb) = 0.0012(uM) | - | Im-nNOS-NOH-Argi
nine
| nNOS-NOH-Arginin
e
Imidazole
| | | Release of Imidazole from complex of NOH-Arginine and Imidazole bound rat brain neuronal Nitric Oxide Synthase. Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. | | 2 |
NOH-Arginine_
binding | 25
(uM^-1 s^-1) | 67500
(s^-1) | Kd(bf) = 2700(uM) | - | NOH-Arginine
Im-nNOS
| Im-nNOS-NOH-Argi
nine
| | | Binding of NOH-Arginine to Imidazole bound rat brainneuronal Nitric Oxide Synthase.Only Kd is known, Kf and Kb need to be approximatedaccordingly to match kinetic profiles. Due to lack ofappropriate graphs the choice of Kf and Kb here isarbitrary and matches only the Kd.Kd = 2.7mM = 2700uM. Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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