NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Accession Type:
Pathway
NOHArginine
NOHArginine
 Molecule
 Reaction

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Reaction List for pathway NOHArginine (Pathway Number 311)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 Imidazole_
release
kf
(s^-1)
0.07
(uM^-1 s^-1)
Kd(cb) = 0.0012(uM)-
  • Im-nNOS-NOH-Argi
    nine

  • nNOS-NOH-Arginin
    e

    Imidazole
  •   Release of Imidazole from complex of NOH-Arginine and Imidazole bound rat brain neuronal Nitric Oxide Synthase. Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51.
    2 NOH-Arginine_
    binding
    kf
    (uM^-1 s^-1)
    67500
    (s^-1)
    Kd(bf) = 2700(uM)-NOH-Arginine
    Im-nNOS
  • Im-nNOS-NOH-Argi
    nine

  •   Binding of NOH-Arginine to Imidazole bound rat brainneuronal Nitric Oxide Synthase.Only Kd is known, Kf and Kb need to be approximatedaccordingly to match kinetic profiles. Due to lack ofappropriate graphs the choice of Kf and Kb here isarbitrary and matches only the Kd.Kd = 2.7mM = 2700uM. Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51.


    Pathway Details   Molecule List  Enzyme List  Reaction List  


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.