 |  |  PLA2 |
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Reaction List for pathway Ras (Pathway Number 58) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
dephosph-GAP | 0.1
(s^-1) | 0
(s^-1) | - | - | GAP*
| GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 2 |
dephosph-GEF | 1
(s^-1) | 0
(s^-1) | - | - | GEF*
| inact-GEF
| | 3 |
Ras-intrinsic-GT
Pase | 0.0001
(s^-1) | 0
(s^-1) | - | - | GTP-Ras
| GDP-Ras
| | | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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