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Reaction List for pathway NOS (Pathway Number 90) |
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| Name | Kf | Kb | Kd | tau | Substrate | Product | |
| 1 | Ca-CaMbind_nNOS | 3.25 (uM^-1 s^-1) | 0.05 (s^-1) | Kd(bf) = 0.0154(uM) | - | nNOS CaM-Ca4 | Ca-CaMnNOS |
| Those binding CaM have a high Kd, including nNOS, ~<=10nM. The binding of CaM to nNOS has been demonstrated to act as the trigger necessary for electron transfer and catalytic activity. (Marletta, Biochemistry, 1997;36:12337-12345). | |||||||
| 2 | dephosporyl | 13.9 (s^-1) | 0 (s^-1) | - | - | NOS* | nNOS |
| kf -13.9 These rates used to keep the basal level of nNOS at reasonable experimental levels. | |||||||
| Pathway Detail | Molecule List | Enzyme List | Reaction List |