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Reaction List for pathway NOS (Pathway Number 90) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
Ca-CaMbind_nNOS | 3.25
(uM^-1 s^-1) | 0.05
(s^-1) | Kd(bf) = 0.0154(uM) | - | nNOS
CaM-Ca4
| Ca-CaMnNOS
| | | Those binding CaM have a high Kd, including nNOS, ~<=10nM. The binding of CaM to nNOS has been demonstrated to act as the trigger necessary for electron transfer and catalytic activity. (Marletta, Biochemistry, 1997;36:12337-12345). | | 2 |
dephosporyl | 13.9
(s^-1) | 0
(s^-1) | - | - | NOS*
| nNOS
| | | kf -13.9 These rates used to keep the basal level of nNOS at reasonable experimental levels. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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