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Molecule List for pathway PP1 (Pathway Number 218) in Accession MAPK_network_2003 (Accession Number 50) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
  arrow indicates that ordering is done according to ascending or descending order.
The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
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Name | Accession
Type | Initial
Conc.
(uM) | Volume
(fL) | Buffered | Sum Total Of | | 1 | I1 | Network | 1.8 | 0 | No | - | | | I1 is a 'mixed' inhibitor, but at high enz concs it looks like a non-compet inhibitor (Foulkes et al Eur J Biochem 132 309-313 9183). We treat it as non-compet, so it just turns the enz off without interacting with the binding site. Cohen et al ann rev bioch refer to results where conc is 1.5 to 1.8 uM. In order to get complete inhib of PP1, which is at 1.8 uM, we need >= 1.8 uM. | | 2 | I1* | Network | 0.001 | 0 | No | - | | | Dephosph is mainly by PP2B | | 3 | PP1-I1 | Network | 0 | 0 | No | - | | 4 | PP1-I1* | Network | 0 | 0 | No | - |
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