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Parameters for SOCS1_knockout (Pathway Number 294) Pathway Layout
Pathway Basic Parameters | Pathway Name | SOCS1_knockout | | Pathway Entry Number | 294 | | Accession Number | 67 | | Accession Name | SOCS1_knockout | | Species | mouse | | Tissue | Liver | | CellCompartment | Nucleus , cytoplasm | | Related Pathways |
| | Notes | This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1 has been knocked out i.e it formation is not shown.
The graphs are almost similar to the graphs as shown in the paper but STAT1n graph has some ambiguities. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.
| Statistics Conversion formatThis pathway is part of accession 67 and is completely specified in the file acc67.g.
There is no separate files for just this pathway. |
Pathway Detail Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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