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SOCS1_knockout
SOCS1_knockoutSOCS1_knockout
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Molecule List for pathway SOCS1_knockout (Pathway Number 294)

 Name Initial Conc. (uM) Volume (fL) Buffered
1AV00.0016667No
   
2AV_degraded00.0016667Yes
    Remains of AV Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
3dup_mRNASc00.0016667No
    Duplicate of the mRNAc Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
4dup_STAT1n*-STAT1n*00.0016667No
    Duplicate of the STAT1c dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
5IFN0.010.0016667Yes
    IFN gamma liganding to the IFN gamma receptor that has JAK bound to its intracellular domain IFN = 10nM = 0.01uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
6IFNR00.0016667No
    Formation of IFNR Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
7IFNRJ00.0016667No
    IFN gamma liganding to the IFN gamma receptor that has JAK bound to its intracellular domain Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
8IFNRJ200.0016667No
    Dimer of IFN gamma liganding to the IFN gamma receptor that has JAK bound to its intracellular domain Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
9IFNRJ2*00.0016667No
    Phosphorylated dimer of IFN gamma liganding to the IFN gamma receptor that has JAK bound to its intracellular domain Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
10IFNRJ2*-SHP-200.0016667No
    Phosphorylated IFNRJ dimer bound to SH2 domain containing tyrosine phosphatase 2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
11IFNRJ2*-STAT1c00.0016667No
    STAT1c complexed with phosphorylated IFNRJ dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
12IFNRJ2*-STAT1c*00.0016667No
    Phosphorylated STAT1c complexed with phosphorylated IFNRJ dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
13IFNRJ2*-STAT1c-SHP200.0016667No
    Formation of IFNRJ2*-STAT1c-SHP2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
14IFNRJ_00.0016667No
    Formation of IFNJR2_ Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
15JAK0.020.0016667No
    JAK: Janus Kinase JAK = 20 nM = 0.02 uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
16mRNASc00.0016667No
    Cytoplasmic fraction of mRNA transcribed from DNA by STAT1 activation factors Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
17mRNASn00.0016667No
    Nuclear fraction of mRNA transcribed from DNA by STAT1 activation factors. Note: This reaction has been knocked out so there will be no mRNASn formation. Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
18mRNAVc00.0016667No
    mRNAVc in the cytoplasm Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
19mRNAVc_dupli00.0016667No
    Duplicate of mRNAVc Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;19-0-196.
20mRNAVc_remain00.0016667Yes
    Remains of mRNAVc Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196.
21mRNAVn00.0016667No
    Transcription of mRNAVn Note: This reaction is now in the paper but in the data sheet provided by author. Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
22mRNA_remain00.0016667Yes
    mRNAc degraded in cytoplasm Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
23PPN0.060.0016667No
    PPX: Unidentified phosphatase in the nucleus PPX = 60nM = 0.06uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
24PPN-STAT1n*00.0016667No
    Phosphorylated STAT1n bound to nucleoplasmic phosphatase Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
25PPN-STAT1n*-STAT1n*00.0016667No
    Phosphorylated STAT1n dimer bound to nucleoplasmic phosphatase Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
26PPX0.050.0016667No
    PPX: Unidentified phosphatase in the cytoplasm PPX = 50nM = 0.05uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
27PPX-STAT1c*00.0016667No
    Phosphorylated STAT1c bound to cytoplasmic phosphatase Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
28PPX-STAT1c*-STAT1c*00.0016667No
    Phosphorylated STAT1c dimer bound to cytoplasmic phosphatase Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
29R0.010.0016667No
    JAK binds to the intracellular domain of the IFN gamma receptor R = 10 nM = 0.01 uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
30RJ00.0016667No
    JAK bound to the intracellular domain of the IFN gamma receptor Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
31SHP-20.10.0016667No
    SHP-2: SH2 domain-containing tyrosine phosphatase 2 SHP-2 = 100nM = 0.1uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
32SOCS100.0016667No
    SOCS1: Suppressor of cytokine signaling-1 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
33SOCS1-IFNR2*-SHP200.0016667No
    SOCS1-IFNRJ2*-SHP2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
34SOCS1-IFNRJ2*00.0016667No
    SOCS1 complexed with phosphorylated IFNRJ dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
35SOCS1-IFNRJ2*-STAT1c00.0016667No
    STAT1 bound to SOCS1 complexed with phosphorylated IFNRJ dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
36SOCS1-IFNRJ2*-STAT1c-SHP-200.0016667No
    SHP-2 bound to phosphorylated IFNRJ dimer complexed with SOCS1 and STAT1 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
37SOCS1_Deg00.0016667Yes
    Degraded SOCS1 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
38STAT1c10.0016667No
    STAT: Signal Transducer and Activator of Transcription STAT1c binds to IFNRJ2* and is phosphorylated by JAK. The phosphorylated STAT1 forms a homodimer which is translocated to the nucleus and works as transcription factors. STAT1c = 1000nM = 1uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
39STAT1c*00.0016667No
    STAT: Signal Transducer and Activator of Transcription Cytoplasmic fraction of phosphorylated STAT1 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
40STAT1c*-STAT1c*00.0016667No
    Cytoplasmic fraction of phosphorylated STAT1 dimers Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
41STAT1n00.0016667No
    STAT: Signal Transducer and Activator of Transcription Nucleoplasmic fraction of STAT1 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
42STAT1n*00.0016667No
    STAT: Signal Transducer and Activator of Transcription Nucleoplasmic fraction of phosphorylated STAT1 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
43STAT1n*-STAT1n*00.0016667No
    Nucleoplasmic fraction of phosphorylated STAT1 dimers Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
44Transcription_comp20.0010.0016667Yes
    Transcription complex for mRNAVn Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
45Transcription_complex0.0010.0016667Yes
    DNA to which STAT1 is bound along with other transcription factors Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

Summed Molecule List

  Target Inputs
1 dup_mRNAScmRNASc
Duplicate of the mRNAc Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
2 dup_STAT1n*-STAT1n*STAT1n*-STAT1n*
Duplicate of the STAT1c dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
3 mRNAVc_duplimRNAVc
Duplicate of mRNAVc Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;19-0-196.


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