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Parameters for Shared_Object_Ajay_Bhalla_2007_Bistable (Pathway Number 363) Pathway Layout
Pathway Basic Parameters | Pathway Name | Shared_Object_Ajay_Bhalla_2007_Bistable | | Pathway Entry Number | 363 | | Accession Number | 79 | | Accession Name | Ajay_Bhalla_2007_Bistable | | Species | Rat | | Tissue | Hippocampal CA1 | | CellCompartment | Dendrite | | Related Pathways |
| | Notes | This is a model of ERKII signaling which is bistable due to feedback. The feedback occurs through ERKII phosphorylation of phospholipase A2 (PLA2), leading to increased production of arachidonic acid (AA), which activates protein kinase C (PKC) which activates c-Raf which is upstream of ERKII.
The model is a highly simplified variant of more detailed bistable models of MAPK signaling (Bhalla US, Iyengar R. Science. 1999 Jan 15;283(5400):381-7, Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80)
| Statistics Conversion formatThis pathway is part of accession 79 and is completely specified in the file acc79.g.
There is no separate files for just this pathway. |
Pathway Detail Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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