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Accession Type:
Network
Ajay_Bhalla_
2007_Bistable
Shared_Object_
Ajay_Bhalla_
2007_Bistable
PKC
PLA2
MAPK
Ras
CaM

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Accession information for Ajay_Bhalla_2007_Bistable (Accession Number 79)

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Accession Basic Parameters

Name Ajay_Bhalla_2007_Bistable
Accession Type Network
Transcriber Upinder S. Bhalla, NCBS
Developer Upinder S. Bhalla, NCBS
Entry Date (YYYY-MM-DD) 2006-12-08
Species Rat
Tissue Hippocampal CA1
Cell Compartment Dendrite
Source Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87
Methodology Semi-Quantitative match to experiments
Model Implementation Exact GENESIS implementation
Model Validation Replicates original data
Notes This is a model of ERKII signaling which is bistable due to feedback. The feedback occurs through ERKII phosphorylation of phospholipase A2 (PLA2), leading to increased production of arachidonic acid (AA), which activates protein kinase C (PKC) which activates c-Raf which is upstream of ERKII.
The model is a highly simplified variant of more detailed bistable models of MAPK signaling (Bhalla US, Iyengar R. Science. 1999 Jan 15;283(5400):381-7, Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80)

Conversion formats

FormatFile
Native Format (GENESIS format)    acc79.g   
MATLAB format    acc79.m   
SBML format    acc79.xml   



Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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