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Accession information for CO_activation_of_GC (Accession Number 28)
Accession Basic Parameters
| Name ||CO_activation_of_GC |
| Accession Type ||Pathway|
| Transcriber ||Sudhir Sivakumaran, NCBS|
| Developer ||Sudhir Sivakumaran, NCBS|
| Entry Date (YYYY-MM-DD) || 2002-01-22|
| Species ||Bovine|
| Tissue ||Lungs|
| Cell Compartment ||Cytosol|
| Source ||In-house |
| Methodology ||Quantitative match to experiments, Qualitative|
| Model Implementation ||Exact GENESIS implementation|
| Model Validation ||Replicates orginal data, Approximates original data|
| Notes || Carbon Monoxide is an activator of soluble Guanylyl Cyclase and has been implicated as a neuronal messenger [Ingi T. et al. Neuron (1996) 16(4):835-42].|
CO binds to the heme group on sGC, similar to NO binding. Exogenous CO at similar conc. to endogenous levels were used to study the extent of activation of GC. Olfactory receptor neurons were used by Ingi et al., to investigate the relationship of CO to cGMP levels, as these cells have high levels of HO activity but no NOS activity.
Kharitonov VG. et al. Proc Natl Acad Sci U S A. (1995) 92(7):2568-71 and
Kharitonov VG. et al. Biochemistry (1999) 38(33):10699-706 report the presence of a six coordinate and a five coordinate intermediate of carboxy GC, induced by CO. Considering that activation of sGC by CO is similar in almost all tissues, some rates have been taken from original published works cited as references in Kharitonov et al., and Ingi et al., the primary datasources, this model is based on.
|Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR |
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