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Enzyme List for pathway PKA (Pathway Number 250) in Accession AMPAR_traff_model1 (Accession Number 60)

Entries are grouped according to Pathway Number and they are alternately color coded using

and

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	Enzyme Molecule / Enzyme Activity	Pathway Name / Pathway No.	Km (uM)	kcat (s^-1)	Ratio (k2/k3)	Enzyme Type	Reagents
1	PKA-active / phosph-PDE	PKA Pathway No. 250	7.50008	9	4	explicit E-S complex	Substrate: cAMP-PDE Product : cAMP-PDE*
	Same rates as PKA-phosph-I1
2	PKA-active / PKA-phosph-I1	PKA Pathway No. 250	7.50008	9	4	explicit E-S complex	Substrate: I1 Product : I1*
	#s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
3	PKA-active / PKA-phosph-I1_ PSD	PKA Pathway No. 250	7.50008	9	4	explicit E-S complex	Substrate: I1 Product : I1*
4	PKA-active / PKA[17]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A_B Product : A845*_B
5	PKA-active / PKA[16]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A831_B Product :* A831845_B
6	PKA-active / PKA[18]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A_B831* Product : A845_B831
7	PKA-active / PKA[19]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A831_B831 Product : A831845_B831*
8	PKA-active / PKA[20]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A_B Product : A_B845*
9	PKA-active / PKA[21]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A831_B Product :* A831_B845
10	PKA-active / PKA[22]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A_B831* Product : A_B831845
11	PKA-active / PKA[23]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A831_B831 Product : A831_B831845*
12	PKA-active / PKA[24]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A_B845* Product : A845_B845
13	PKA-active / PKA[25]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A831_B845 Product : A831845_B845*
14	PKA-active / PKA[26]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A_B831845 Product : A845_B831845*
15	PKA-active / PKA[27]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A831_B831845* Product : A835845_ B835845
16	PKA-active / PKA[28]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A845_B Product :* A845_B845
17	PKA-active / PKA[29]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A831845_B Product : A831845_B845*
18	PKA-active / PKA[30]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A845_B831 Product : A845_B831845*
19	PKA-active / PKA[31]	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A831845_B831* Product : A835845_ B835845
20	PKA-active / PKA	PKA Pathway No. 250	7.50021	6	4	explicit E-S complex	Substrate: A_B845* Product : A845_B845

Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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