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Enzyme List for pathway PLC_g (Pathway Number 356) in Accession Ajay_Bhalla_2004_Feedback_Tuning (Accession Number 78)

Entries are grouped according to Pathway Number and they are alternately color coded using  and   color.
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  Enzyme Molecule /

 Enzyme Activity
Pathway Name / 
Pathway No.
Km
(uM)
kcat
(s^-1)
Ratio
(k2/k3)
Enzyme TypeReagents
1 Ca.PLC_g /
PIP2_hydrolysis
PLC_g

Pathway No. 356
97.2222144explicit E-S complexSubstrate: 
PIP2
Product : 
DAG
IP3
  Mainly Homma et al JBC 263:14 1988 pp 6592, but these parms are the Ca-stimulated form. It is not clear whether the enzyme is activated by tyrosine phosphorylation at this point or not. Wahl et al JBC 267:15 10447-10456 1992 say that the Ca_stim and phosph form has 7X higher affinity for substrate than control. This is close to Wahl's figure 7, which I am using as reference.
2 Ca.PLC_g* /
PIP2_hydrolysis
PLC_g

Pathway No. 356
19.7917574explicit E-S complexSubstrate: 
PIP2
Product : 
DAG
IP3
  Mainly Homma et al JBC 263:14 1988 pp 6592, but these parms are the Ca-stimulated form. It is not clear whether the enzyme is activated by tyrosine phosphorylation at this point or not. Wahl et al JBC 267:15 10447-10456 1992 say that this has 7X higher affinity for substrate than control.

 
Result: 1 - 2 of 2 rows are displayed



Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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