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Result: 1 - 5 of 5 rows are displayed

Enzyme List for pathway PLA2 (Pathway Number 36) in Accession mkp1_feedback_effects (Accession Number 4)

Entries are grouped according to Pathway Number and they are alternately color coded using  and   color.
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  Enzyme Molecule /

 Enzyme Activity
Pathway Name / 
Pathway No.
Km
(uM)
kcat
(s^-1)
Ratio
(k2/k3)
Enzyme TypeReagents
1 PLA2-Ca* /
kenz
PLA2

Pathway No. 36
205.44explicit E-S complexSubstrate: 
APC
Product : 
AA
  Based on Leslie and Channon 1990 BBA 1045:261, in relation to the other PLA2 inputs (not including MAPK). Ca alone is rather a weak input.
2 PIP2-PLA2* /
kenz
PLA2

Pathway No. 36
2011.044explicit E-S complexSubstrate: 
APC
Product : 
AA
  Based on Leslie and Channon 1990 BBA 1045:261.
3 PIP2-Ca-PLA2* /
kenz
PLA2

Pathway No. 36
20364explicit E-S complexSubstrate: 
APC
Product : 
AA
  Based on AA generation by different stimuli according to Leslie and Channon 1990 BBA 1045:261
4 DAG-Ca-PLA2* /
kenz
PLA2

Pathway No. 36
20604explicit E-S complexSubstrate: 
APC
Product : 
AA
  Based on Leslie and Channon 1990 BBA 1045:261.
5 PLA2*-Ca /
kenz
PLA2

Pathway No. 36
201204explicit E-S complexSubstrate: 
APC
Product : 
AA
  This form should be 3 to 6 times as fast as the Ca-only form, from Lin et al 1993 Cell 269-278 Nemenoff et al 1993 JBC 268:1960 Several forms contribute to the Ca-stimulated form, so this rate has to be a factor larger than their total contribution. I assign Vmax as the scale factor here because there is lots of APC substrate, so all the PLA2 complex enzymes are limited primarily by Vmax.

 
Result: 1 - 5 of 5 rows are displayed



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