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Molecule List for pathway PP2B (Pathway Number 83) in Accession Synaptic_Network (Accession Number 16)
| Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.|
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The entries are grouped according to Pathway Number and are alternately color coded using and color.
|Buffered||Sum Total Of|
|1|| CaMCa2-CANAB||Network||0||1000||No||- |
| || Ca2.CaM.Ca4.CaNAB The CaM has only 2 calciums attached, but CaNAB has all 4. This contributes equally to enzyme activity along with the Ca3 and Ca4 forms.|
|2|| CaMCa3-CaNAB||Network||0||1000||No||- |
| || Ca3.CaM.Ca4.CaNAB This is assumed to have the same enzymatic activity as the other Ca states of CaM bound to CaNAB. Hence I just put this into a summation with the other states and utilize the sum for the enzymatic steps.|
|3|| CaMCa4-CaNAB||Network||0||1000||No||- |
| || Ca4.CaM.Ca4.CaNAB. This form is fullly loaded with Ca. Its activity is assumed to be the same as the lower Ca-bound forms of CaM.Ca4.CaNAB. |
|4|| CaNAB||Network||1||1000||No||- |
| || Calcineurin A and B subunits. We assume that the A and B subunits of PP2B are always bound under physiological conditions. Tallant and Cheung '83 Biochem 22 3630-3635 have conc in many species, average for mammalian brain is around 1 uM.|
|5|| CaNAB-Ca2||Network||0||1000||No||- |
| || Form of CaN with two Calciums bound.|
|Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR |
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