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Molecule Parameter List for IP1(1)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP1(1) participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000211

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP1(1) acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP1(1)
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    01000No
    Inositol (1)monophsophate Basal Conc ~ 44uM : Ackermann et al, BiochemJ 1987, 242(2): 517-24 IP metabolism maintains only a tenth of this level while the rest is generated from PtdIns metabolism.

    IP1(1) acting as a Product of an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP2_3pase2  /
    ip2_3pase2
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    3.7000139.24explicit E-S complexSubstrate
    IP2(13)

    Product
    IP1(1)
        from Caldwell et al, JBC 266; 1991
    2IP2_3pase1  /
    ip2_3pase1
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    0.799992117.334explicit E-S complexSubstrate
    IP2(13)

    Product
    IP1(1)
        from Caldwell et al, JBC 266; 1991 enzyme activity was assayed for the monomeric form of the enzyme

    IP1(1) acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    1pase-on
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    0.3572
    (uM^-1 s^-1)
    45.72
    (s^-1)
    Kd(bf) = 128.0005(uM)-Substrate
    IP1(1)
    IP1_pase

    Product
    ip1_1pase_cmplx
    Rates derived from Km for Ins(1)P1-1phosphatase: Gee et al, Biochem J 249; 1988.

    IP1(1) acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    ip1_syn
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    0.11
    (s^-1)
    0
    (s^-1)
    --Substrate
    inositol

    Product
    IP1(1)
    This rxn. maintains levels of Ins(1)P1 at 44 uM basal. Actually, 90% of Ins(1)P1 is generated from PtdIns degradation (Ackermann et al, Biochem J 242(2), 1987: 517-24) but for simplicity we use a back rxn. from Inositol to generate this conc.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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