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Molecule Parameter List for IP3-56Kcmplx

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP3-56Kcmplx participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000021

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP3-56Kcmplx acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP3-56Kcmplx
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    01000No
    enzyme substrate complex of IP3 56-K and Ins(134)P3. Complex exclusively modeled as reaction generates ratio of products, and because 5-kinase is reversible due to large Ins(1345)P4 backflux

    IP3-56Kcmplx acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    16kinase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    0.256
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    IP3-56Kcmplx

    Product
    IP3-56K_IP4-1K
    IP4(1346)
      Kf = Vmax for IP3 56-K from Yang and Shears, Biochem J 2000; 351:551-555 Enzyme reversibility reported in Ho et al, Curr Biol 2002, 12: 1-20. But backflow calculations do not show that Kb needs to be incorporated
    25kinase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    0.0701
    (s^-1)
    0.006
    (uM^-1 s^-1)
    Kd(cb) = 0.086(uM)-Substrate
    IP3-56Kcmplx

    Product
    IP3-56K_IP4-1K
    IP4(1345)
      Kf = 0.274 times Vmax of IP3 56-K as product ratio of Ins(1345)P4 : Ins(1346)P4 is 1 : 2.3-5 from Wilson and Majerus, JBC 271; 1996 Kb ascertained from dG calculations for equilibrium conditions., for a dG = -10 kJ/mol Also enzyme reversibility reported in Ho et al, Curr Biol 2002, 12: 1-20

    IP3-56Kcmplx acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    IP3-Kcmplx-on
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    4.2666
    (uM^-1 s^-1)
    1.024
    (s^-1)
    Kd(bf) = 0.24(uM)-Substrate
    IP3(134)
    IP3-56K_IP4-1K

    Product
    IP3-56Kcmplx
    Kf and Kb are equivalent to k1 and k2 for InsP3 56-K, calculated from enzyme Km and Vmax: Yang and Shears, BiochemJ 2000, 351: 551-555



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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