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Molecule Parameter List for inositol

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
inositol participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000013

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    inositol acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    inositol
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 145_dephos
    Pathway No. : 153
    5001000Yes

    inositol acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    ip1_syn
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    0.11
    (s^-1)
    0
    (s^-1)
    --Substrate
    inositol

    Product
    IP1(1)
    This rxn. maintains levels of Ins(1)P1 at 44 uM basal. Actually, 90% of Ins(1)P1 is generated from PtdIns degradation (Ackermann et al, Biochem J 242(2), 1987: 517-24) but for simplicity we use a back rxn. from Inositol to generate this conc.

    inositol acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1IP1(3)_deg
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    35
    (s^-1)
    0.336
    (s^-1)
    Keq = 0.0096(uM)0.028secSubstrate
    IP1(3)

    Product
    inositol
      Kf and Kb based on levels of Ins(3)P1. Kb necessary as energetics calculations show backflow from inositol to be significant.
    21pase-off
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    11.43
    (s^-1)
    0.0008
    (uM^-1 s^-1)
    Kd(cb) = 0.0001(uM)-Substrate
    ip1_1pase_cmplx

    Product
    IP1_pase
    inositol
      Kf = Vmax for Ins(1)P1-1phosphatase: Gee et al, Biochem J 249, 1988. Kb necessary as estimated from percent inositol backflux calculations. This contributes to maintain Ins(1)P1 at 10% of its actual pool.
    34pase-off
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 145_dephos
    Pathway No. : 153
    39.33
    (s^-1)
    0.0021
    (uM^-1 s^-1)
    Kd(cb) = 0.0001(uM)-Substrate
    ip1_4pase_cmplx

    Product
    IP1_pase
    inositol
      Kf = Vmax for Ins(4)P1 4-phosphatase: Gee et al, Biochem J 249, 1988. Kb adjusted to generate reported basal levels of Ins(4)P1 = 10% of Ins(1)P1 ~ 4uM



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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