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Molecule Parameter List for CDK2cycA*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CDK2cycA* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • CDK2-CyclinA_
    activation_
    pathway
  • 42Pathway
    CDK2-CyclinA 
    In this version of the CDK2/Cyclin A complex activation there is discrepancy in the first curve which plots the binding reaction of CDK2 and Cyclin A expressed in E. coli. With the published rate constants the simulation does not match the published graph (Fig.1B) in Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53.

    CDK2cycA* acting as a Molecule in  
    CDK2-CyclinA_activation_pathway Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CDK2cycA*
  • CDK2-CyclinA_
    activation_
    pathway

    Accession No. : 42
  • CDK2-CyclinA
    Pathway No. : 190
    0999.98No
    CoInit = 0 uM Morris et al (2002 june 28) J Biol Chem. 277(26):23847-53
    Reaction scheme 1 pp.23848

    CDK2cycA* acting as a Summed Molecule in  
    CDK2-CyclinA_activation_pathway Network
    Accession NamePathway NameTargetInput
  • CDK2-CyclinA_
    activation_
    pathway

    Accession No. : 42
  • CDK2-CyclinA
    Pathway No. : 190
    total_fluorescenceCDK2cycA
    CDK2cycA*
  • basal_
    fluorescence

  • The volume of this pool is scaled to 1/5.8 times the general volume in the model (1e-15 m^3) so that the range of fluorescent changes is 0.058 for complete consumption of the fluorophore (0.1 uM of Cdk2). The volume is therefore 0.1724e-15

    CDK2cycA* acting as a Product in a reaction in  
    CDK2-CyclinA_activation_pathway Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Activation
  • CDK2-CyclinA_
    activation_
    pathway

    Accession No. : 42
  • CDK2-CyclinA
    Pathway No. : 190
    0.813
    (s^-1)
    0.557
    (s^-1)
    Keq = 0.6851(uM)0.73secSubstrate
    CDK2cycA

    Product
    CDK2cycA*
    Morris et al 2002 JBC 277(26): 23847--23853 kf and kb values not published kobs2 = 2.5 +- 0.1 /sec kf=0.813/sec and kb=0.557/sec used in simulation



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