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Molecule Parameter List for PKC-Ca-DAG

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-Ca-DAG participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
PKC_200348Pathway
PKC_2003 PKC 
This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here.

PKC-Ca-DAG acting as a Molecule in  
PKC_2003 Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PKC-Ca-DAGPKC_2003
Accession No. : 48
PKC
Pathway No. : 200
01000No

PKC-Ca-DAG acting as a Substrate in a reaction in  
PKC_2003 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
PKC-DAG-to-membPKC_2003
Accession No. : 48
PKC
Pathway No. : 200
1
(s^-1)
0.1
(s^-1)
Keq = 0.1(uM)0.909secSubstrate
PKC-Ca-DAG

Product
PKC-DAG-memb*
Raise kb from .087 to 0.1 to match data from Shinomura et al. Lower kf from 1.155 to 1.0 to match data from Shinomura et al.

PKC-Ca-DAG acting as a Product in a reaction in  
PKC_2003 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
PKC-act-by-DAGPKC_2003
Accession No. : 48
PKC
Pathway No. : 200
0.008
(uM^-1 s^-1)
8.6348
(s^-1)
Kd(bf) = 1079.377(uM)-Substrate
DAG
PKC-Ca

Product
PKC-Ca-DAG
Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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