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Molecule Parameter List for PP2A

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PP2A participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1020000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
CaMKII_200349Network
Shared_Object_CaMKII_2003 CaMKII CaM 
PP1 PP2B 
Model of regulation of CaMKII by Calcium, including parallel excitatory input from CaM and inhibitory input from PP1 as regulated by Calcineurin and PKA. Cell type: neuronal.
Bhalla US. Biophys J. 2004 Aug;87(2):733-44.

PP2A acting as a Molecule in  
CaMKII_2003 Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PP2ACaMKII_2003
Accession No. : 49
  • Shared_Object_
    CaMKII_2003

    Pathway No. : 201
  • 0.121000No

    PP2A acting as an Enzyme in  
    CaMKII_2003 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP2A /
  • PP2A-dephosph-I1
  • CaMKII_2003
    Accession No. : 49
  • Shared_Object_
    CaMKII_2003

    Pathway No. : 201
  • 7.8282864.16667explicit E-S complexSubstrate
    I1*

    Product
    I1
        PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
    2PP2A /
  • PP2A-dephosph-PP
    1-I*
  • CaMKII_2003
    Accession No. : 49
  • Shared_Object_
    CaMKII_2003

    Pathway No. : 201
  • 7.8282864.16667explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
        k1 changed from 3.3e-6 to 6.6e-6



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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