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Molecule Parameter List for IR**

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IR** participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000120

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • simple_AMPAR_
    traff_model2
  • 61Network
    Shared_Object_simple_AMPAR_traff_model2 Membrane Internal 
    This is a highly simplified model of the AMPAR trafficking cycle that exhibits bistability. It is model 2 from Hayer and Bhalla, PLoS 2005. Its main purpose it to illustrate how the bistability arises.

    IR** acting as a Molecule in  
    simple_AMPAR_traff_model2 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IR**
  • simple_AMPAR_
    traff_model2

    Accession No. : 61
  • Internal
    Pathway No. : 256
    00.09No

    IR** acting as a Product of an Enzyme in  
    simple_AMPAR_traff_model2 Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PKA-active  /
  • internal-PKA-act
    [1]
  • simple_AMPAR_
    traff_model2

    Accession No. : 61
  • Shared_Object_
    simple_AMPAR_
    traff_model2

    Pathway No. : 254
  • 3.7499564explicit E-S complexSubstrate
    IR*

    Product
    IR**
    Note that Km is halved from the detailed model, as the reaction represents enzyme activity on 2 subunits.

    IR** acting as a Substrate in a reaction in  
    simple_AMPAR_traff_model2 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1to_memb
  • simple_AMPAR_
    traff_model2

    Accession No. : 61
  • Shared_Object_
    simple_AMPAR_
    traff_model2

    Pathway No. : 254
  • 0.0002
    (#^-1 s^-1)
    0.008
    (s^-1)
    Not applicable**-Substrate
    Anchor
    IR**

    Product
    MR**
    2degradation[1]
  • simple_AMPAR_
    traff_model2

    Accession No. : 61
  • Shared_Object_
    simple_AMPAR_
    traff_model2

    Pathway No. : 254
  • 0
    (s^-1)
    0
    (s^-1)
    Not applicable**-Substrate
    IR**

    Product
    Bulk_AMPAR
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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