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Molecule Parameter List for PKA-active

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*PKA-active* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	4	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
simple_AMPAR_ traff_model2	61	Network	Shared_Object_simple_AMPAR_traff_model2, Membrane, Internal
This is a highly simplified model of the AMPAR trafficking cycle that exhibits bistability. It is model 2 from Hayer and Bhalla, PLoS 2005. Its main purpose it to illustrate how the bistability arises.

PKA-active acting as a Molecule in simple_AMPAR_traff_model2 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PKA-active	simple_AMPAR_ traff_model2 Accession No. : 61	Shared_Object_ simple_AMPAR_ traff_model2 Pathway No. : 254	0.0185	0.09	Yes

PKA-active acting as an Enzyme in simple_AMPAR_traff_model2 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PKA-active / memb-PKA-act	simple_AMPAR_ traff_model2 Accession No. : 61	Shared_Object_ simple_AMPAR_ traff_model2 Pathway No. : 254	3.74995	6	4	explicit E-S complex	Substrate MR Product MR*
	Note halving of Km. See notes for internal-PKA-act enzymatic step.
2	PKA-active / internal-PKA-act	simple_AMPAR_ traff_model2 Accession No. : 61	Shared_Object_ simple_AMPAR_ traff_model2 Pathway No. : 254	3.74995	6	4	explicit E-S complex	Substrate IR Product IR*
	Note that Km is halved from the main model, from 7.5 to 3.75. This is because here we lump two subunits into one, thus double the effective substrate conc that the enzyme must deal with. We thank an anonymous reviewer for pointing this out.
3	PKA-active / memb-PKA-act[1]	simple_AMPAR_ traff_model2 Accession No. : 61	Shared_Object_ simple_AMPAR_ traff_model2 Pathway No. : 254	3.74995	6	4	explicit E-S complex	Substrate MR* Product MR**
	Note halving of Km. See notes for internal-PKA-act enzyme step.
4	PKA-active / internal-PKA-act [1]	simple_AMPAR_ traff_model2 Accession No. : 61	Shared_Object_ simple_AMPAR_ traff_model2 Pathway No. : 254	3.74995	6	4	explicit E-S complex	Substrate IR* Product IR**
	Note that Km is halved from the detailed model, as the reaction represents enzyme activity on 2 subunits.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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