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Molecule Parameter List for IFN

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IFN participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000020

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Jak-Stat_
    Pathway
  • 66Pathway
    Jak-Stat_Pathway 
    This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
    This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway.
    Note: There are a few ambiguities in the paper like initial concentration of IFN and some reactions were missing in the paper that were employed for obtaining the results. The graphs are almost similar to the graphs as shown in the paper but still some ambiguities regarding the concentration are there. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

    IFN acting as a Molecule in  
    Jak-Stat_Pathway Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IFN
  • Jak-Stat_
    Pathway

    Accession No. : 66
  • Jak-Stat_
    Pathway

    Pathway No. : 293
  • 0.010.0016667Yes
    IFN gamma liganding to the IFN gamma receptor that has JAK bound to its intracellular domain. IFN = 10nM = 0.01uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

    IFN acting as a Substrate in a reaction in  
    Jak-Stat_Pathway Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1IFN_binding
  • Jak-Stat_
    Pathway

    Accession No. : 66
  • Jak-Stat_
    Pathway

    Pathway No. : 293
  • 20
    (uM^-1 s^-1)
    0.02
    (s^-1)
    Kd(bf) = 0.001(uM)-Substrate
    IFN
    RJ

    Product
    IFNRJ
      Binding of JAK to the intracellular domain of the IFN gamma receptor Kf = 20*10e+06 /M/sec = 20/uM/sec Kb = 0.02 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    2IFN-R_bind
  • Jak-Stat_
    Pathway

    Accession No. : 66
  • Jak-Stat_
    Pathway

    Pathway No. : 293
  • 20
    (uM^-1 s^-1)
    0.02
    (s^-1)
    Kd(bf) = 0.001(uM)-Substrate
    IFN
    R

    Product
    IFNR
      Binding reaction of IFN + R. kf = 20/sec/uM kb = 0.02/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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