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Molecule Parameter List for Homoarginine

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Homoarginine participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
HomoArginine73Pathway
HomoArginine 
This model is taken from the Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51 This model shows kinetic binding of HomoArginine to neuronal nitric oxide synthase.
Model shows the substrate (Homorginine) binding to nNOS in a two-step reversible fashion. First there is rapid binding equilibrium between Im-nNOS and Homoarginine to form an intermediate that contains bound imidazole and homoarginine. This is followed by a slower conformational change in the Im-enzyme-substrate complex that is associated with release of bound imidazole and generation of a modified enzyme-substrate complex which is detected due to spectral change. Rates approximated based on data in Table 2. The rates for first reaction are not exact since only Kd known and appropriate graphs do not exist for matching the kinetic profile.

Homoarginine acting as a Molecule in  
HomoArginine Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
HomoarginineHomoArginine
Accession No. : 73
HomoArginine
Pathway No. : 309
60000.0016667No
Homoarginine, an alternative substrate forneuronal Nitric Oxide Synthase Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51.

Homoarginine acting as a Substrate in a reaction in  
HomoArginine Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
  • Homoarginine_
    binding
  • HomoArginine
    Accession No. : 73
    HomoArginine
    Pathway No. : 309
    25
    (uM^-1 s^-1)
    250000
    (s^-1)
    Kd(bf) = 10000(uM)-Substrate
    Homoarginine
    Im-nNOS

    Product
  • Im-nNOS-Homoargi
    nine

  • Binding of Homoarginine to Imidazole bound rat brainneuronal Nitric Oxide Synthase.Only Kd is known, Kf and Kb need to be approximatedaccordingly to match kinetic profiles. Due to lack of appropriate graphs the choice of Kf and Kb here is arbitrary and matches only the Kd. Kd = 10mM = 10000uM, Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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