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Molecule Parameter List for R2C-cAMP4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
R2C-cAMP4 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2004_PKM_Tuning
  • 76Network
    PKC Shared_Object_Ajay_Bhalla_2004_PKM_tuning PLA2 
    PLCbeta Gq MAPK 
    Ras EGFR Sos 
    PLC_g CaMKII CaM 
    PP1 PP2B PKA 
    AC PKM 
    This model is taken from the Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the reference feedforward model from Figure 8a.

    R2C-cAMP4 acting as a Molecule in  
    Ajay_Bhalla_2004_PKM_Tuning Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    R2C-cAMP4
  • Ajay_Bhalla_
    2004_PKM_Tuning

    Accession No. : 76
  • PKA
    Pathway No. : 326
    01.5No

    R2C-cAMP4 acting as a Substrate in a reaction in  
    Ajay_Bhalla_2004_PKM_Tuning Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Release-C2
  • Ajay_Bhalla_
    2004_PKM_Tuning

    Accession No. : 76
  • PKA
    Pathway No. : 326
    60
    (s^-1)
    18
    (uM^-1 s^-1)
    Kd(cb) = 0.3(uM)-Substrate
    R2C-cAMP4

    Product
    PKA-active
    R2-cAMP4

    R2C-cAMP4 acting as a Product in a reaction in  
    Ajay_Bhalla_2004_PKM_Tuning Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Release-C1
  • Ajay_Bhalla_
    2004_PKM_Tuning

    Accession No. : 76
  • PKA
    Pathway No. : 326
    60
    (s^-1)
    18
    (uM^-1 s^-1)
    Kd(cb) = 0.3(uM)-Substrate
    R2C2-cAMP4

    Product
    PKA-active
    R2C-cAMP4
    This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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