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Molecule Parameter List for MAPKK* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color. | Statistics | Accession and Pathway Details | |
Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_ 2007_ReacDiff2 | 83 | Network | Shared_Object_Ajay_Bhalla_2007_ReacDiff, PKC, MAPK, Ras, CaM, PKM, chain, kinetics, PKC, MAPK, Ras, CaM, PKM, kinetics[1], PKC, MAPK, Ras, kinetics[3], CaM, PKM, kinetics[2], PKC, MAPK, Ras, CaM, PKM, PKC, MAPK, Ras, CaM, PKM, kinetics[4], PKC, MAPK, Ras, CaM, PKM, kinetics[5], PKC, MAPK, Ras, CaM, PKM, kinetics[6], PKC, MAPK, Ras, CaM, PKM, kinetics[7], PKC, MAPK, Ras, CaM, PKM, kinetics[8], PKC, MAPK, Ras, CaM, PKM, kinetics[9], PKC, MAPK, Ras, CaM, PKM, kinetics[10], PKC, MAPK, Ras, CaM, PKM, kinetics[11], PKC, MAPK, Ras, CaM, PKM, kinetics[12], PKC, MAPK, Ras, CaM, PKM, kinetics[13], PKC, MAPK, Ras, CaM, PKM, kinetics[14], PKC, MAPK, Ras, CaM, PKM, kinetics[15], PKC, MAPK, Ras, CaM, PKM, kinetics[16], PKC, MAPK, Ras, CaM, PKM, kinetics[17], PKC, MAPK, Ras, CaM, PKM, kinetics[18], PKC, MAPK, Ras, CaM, PKM, kinetics[19], PKC, MAPK, Ras, CaM, PKM, kinetics[20], PKC, MAPK, Ras, CaM, PKM, kinetics[21], PKC, MAPK, Ras, CaM, PKM, kinetics[22], PKC, MAPK, Ras, CaM, PKM, kinetics[23], PKC, MAPK, Ras, CaM, PKM, kinetics[24], PKC, MAPK, Ras, CaM, PKM, kinetics[25], PKC, MAPK, Ras, CaM, PKM, kinetics[26], PKC, MAPK, Ras, CaM, PKM, kinetics[27], PKC, MAPK, Ras, CaM, PKM, kinetics[28], PKC, MAPK, Ras, CaM, PKM, kinetics[29], PKC, MAPK, Ras, CaM, PKM, kinetics[30], PKC, MAPK, Ras, CaM, PKM, kinetics[31], PKC, MAPK, Ras, CaM, PKM, kinetics[32], PKC, MAPK, Ras, CaM, PKM, kinetics[33], PKC, MAPK, Ras, CaM, PKM, kinetics[34], PKC, MAPK, Ras, CaM, PKM, kinetics[35], PKC, MAPK, Ras, CaM, PKM, kinetics[36], PKC, MAPK, Ras, CaM, PKM, kinetics[37], PKC, MAPK, Ras, CaM, PKM, kinetics[38], PKC, MAPK, Ras, CaM, PKM | This is a 40-compartment reaction-diffusion-transport version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 40 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec In addition, we have a forward (dendrite to soma) transport term of 1 microns/sec. This converts to a rate of 0.1/sec, but applies only to the kf. So the total kf of the diffusion 'reaction' is 0.11 for D = 1 micron^2/sec, and kb is 0.01. If D=0.1 micron^2/sec then kf = 0.101 and kb = 0.001. In addition this model has all molecules buffered in the first and last compartments. This boundary conditions says that the molecules are not drained out of the first compartment, nor do they all pile up in the last one.
The stimulus file pkm_mapk22_transp_endbuf_D1e-13_Fig4CD which was used for the model to replicate Figure 4C and 4D from the paper.
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MAPKK* acting as a Molecule in Ajay_Bhalla_2007_ReacDiff2 Network
Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 686 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 692 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 699 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 704 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 710 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 716 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 722 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 728 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 734 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 740 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 746 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 752 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 758 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 764 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 770 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 776 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 782 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 788 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 794 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 800 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 806 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 812 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 818 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 824 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 830 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 836 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 842 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 848 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 854 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 860 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 866 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 872 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 878 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 884 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 890 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 896 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 902 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 908 | 0 | 1.5 | No | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 679 | 0 | 1.5 | Yes | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 | MAPKK* | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 914 | 0 | 1.5 | Yes | MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992 |
MAPKK* acting as an Enzyme in Ajay_Bhalla_2007_ReacDiff2 Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | 1 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 679 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 2 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 679 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 3 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 686 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 4 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 686 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 5 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 692 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 6 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 692 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 7 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 699 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 8 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 699 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 9 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 704 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 10 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 704 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 11 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 710 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 12 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 710 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 13 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 716 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 14 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 716 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 15 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 722 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 16 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 722 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 17 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 728 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 18 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 728 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 19 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 734 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 20 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 734 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 21 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 740 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 22 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 740 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 23 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 746 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 24 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 746 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 25 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 752 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 26 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 752 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 27 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 758 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 28 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 758 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 29 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 764 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 30 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 764 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 31 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 770 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 32 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 770 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 33 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 776 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 34 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 776 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 35 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 782 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 36 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 782 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 37 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 788 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 38 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 788 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 39 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 794 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 40 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 794 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 41 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 800 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 42 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 800 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 43 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 806 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 44 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 806 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 45 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 812 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 46 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 812 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 47 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 818 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 48 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 818 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 49 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 824 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 50 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 824 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 51 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 830 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 52 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 830 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 53 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 836 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 54 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 836 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 55 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 842 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 56 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 842 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 57 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 848 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 58 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 848 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 59 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 854 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 60 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 854 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 61 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 860 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 62 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 860 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 63 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 866 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 64 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 866 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 65 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 872 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 66 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 872 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 67 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 878 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 68 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 878 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 69 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 884 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 70 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 884 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 71 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 890 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 72 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 890 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 73 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 896 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 74 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 896 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 75 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 902 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 76 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 902 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 77 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 908 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 78 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 908 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. | 79 | MAPKK* / MAPKKtyr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 914 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK
Product MAPK-tyr
| | The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5 | 80 | MAPKK* / MAPKKthr
| Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 914 | 0.0462964 | 0.3 | 4 | explicit E-S complex | Substrate MAPK-tyr
Product MAPK*
| | Rate consts same as for MAPKKtyr. |
MAPKK* acting as a Substrate for an Enzyme in Ajay_Bhalla_2007_ReacDiff2 Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | 1 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 2 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics Pathway No. : 684 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 3 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[1] Pathway No. : 690 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 4 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[2] Pathway No. : 697 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 5 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[3] Pathway No. : 694 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 6 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[4] Pathway No. : 708 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 7 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[5] Pathway No. : 714 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 8 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[6] Pathway No. : 720 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 9 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[7] Pathway No. : 726 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 10 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[8] Pathway No. : 732 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 11 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[9] Pathway No. : 738 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 12 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[10] Pathway No. : 744 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 13 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[11] Pathway No. : 750 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 14 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[12] Pathway No. : 756 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 15 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[13] Pathway No. : 762 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 16 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[14] Pathway No. : 768 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 17 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[15] Pathway No. : 774 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 18 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[16] Pathway No. : 780 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 19 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[17] Pathway No. : 786 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 20 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[18] Pathway No. : 792 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 21 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[19] Pathway No. : 798 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 22 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[20] Pathway No. : 804 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 23 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[21] Pathway No. : 810 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 24 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[22] Pathway No. : 816 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 25 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[23] Pathway No. : 822 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 26 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[24] Pathway No. : 828 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 27 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[25] Pathway No. : 834 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 28 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[26] Pathway No. : 840 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 29 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[27] Pathway No. : 846 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 30 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[28] Pathway No. : 852 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 31 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[29] Pathway No. : 858 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 32 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[30] Pathway No. : 864 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 33 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[31] Pathway No. : 870 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 34 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[32] Pathway No. : 876 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 35 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[33] Pathway No. : 882 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 36 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[34] Pathway No. : 888 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 37 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[35] Pathway No. : 894 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 38 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[36] Pathway No. : 900 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 39 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[37] Pathway No. : 906 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. | 40 | PPhosphatase2A / MAPKK-deph | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | kinetics[38] Pathway No. : 912 | 15.6567 | 6 | 4 | explicit E-S complex | Substrate MAPKK*
Product MAPKK-ser
| | See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms. |
MAPKK* acting as a Product of an Enzyme in Ajay_Bhalla_2007_ReacDiff2 Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | 1 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 679 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 2 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 679 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 3 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 686 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 4 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 686 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 5 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 692 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 6 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 692 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 7 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 699 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 8 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 699 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 9 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 704 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 10 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 704 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 11 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 710 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 12 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 710 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 13 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 716 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 14 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 716 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 15 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 722 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 16 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 722 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 17 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 728 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 18 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 728 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 19 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 734 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 20 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 734 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 21 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 740 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 22 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 740 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 23 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 746 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 24 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 746 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 25 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 752 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 26 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 752 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 27 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 758 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 28 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 758 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 29 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 764 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 30 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 764 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 31 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 770 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 32 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 770 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 33 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 776 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 34 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 776 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 35 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 782 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 36 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 782 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 37 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 788 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 38 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 788 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 39 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 794 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 40 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 794 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 41 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 800 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 42 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 800 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 43 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 806 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 44 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 806 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 45 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 812 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 46 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 812 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 47 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 818 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 48 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 818 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 49 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 824 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 50 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 824 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 51 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 830 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 52 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 830 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 53 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 836 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 54 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 836 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 55 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 842 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 56 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 842 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 57 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 848 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 58 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 848 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 59 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 854 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 60 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 854 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 61 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 860 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 62 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 860 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 63 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 866 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 64 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 866 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 65 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 872 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 66 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 872 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 67 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 878 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 68 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 878 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 69 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 884 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 70 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 884 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 71 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 890 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 72 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 890 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 73 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 896 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 74 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 896 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 75 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 902 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 76 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 902 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 77 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 908 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 78 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 908 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 | 79 | Raf-GTP-Ras / Raf-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 914 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591). | 80 | Raf*-GTP-Ras / Raf*-GTP-Ras.2 | Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83 | MAPK Pathway No. : 914 | 0.159096 | 0.3 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
| | Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6 |
MAPKK* acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff2 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
MAPKK* acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff2 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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