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Molecule Parameter List for MAPKK*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
MAPKK* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences4008040803939

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff2
    		• 83NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff,  PKC,  MAPK,  
    Ras,  CaM,  PKM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[1],  
    PKC,  MAPK,  Ras,  kinetics[3],  CaM,  PKM,  kinetics[2],  PKC,  MAPK,  Ras,  
    CaM,  PKM,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[4],  PKC,  MAPK,  Ras,  CaM,  
    PKM,  kinetics[5],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[6],  PKC,  MAPK,  
    Ras,  CaM,  PKM,  kinetics[7],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[8],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[9],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[10],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[11],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[12],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[13],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[14],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[15],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[16],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[17],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[18],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[19],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[20],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[21],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[22],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[23],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[24],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[25],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[26],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[27],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[28],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[29],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[30],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[31],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[32],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[33],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[34],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[35],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[36],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[37],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[38],  
    PKC,  MAPK,  Ras,  CaM,  PKM 
    This is a 40-compartment reaction-diffusion-transport version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 40 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec In addition, we have a forward (dendrite to soma) transport term of 1 microns/sec. This converts to a rate of 0.1/sec, but applies only to the kf. So the total kf of the diffusion 'reaction' is 0.11 for D = 1 micron^2/sec, and kb is 0.01. If D=0.1 micron^2/sec then kf = 0.101 and kb = 0.001. In addition this model has all molecules buffered in the first and last compartments. This boundary conditions says that the molecules are not drained out of the first compartment, nor do they all pile up in the last one.
    The stimulus file pkm_mapk22_transp_endbuf_D1e-13_Fig4CD which was used for the model to replicate Figure 4C and 4D from the paper.

    MAPKK* acting as a Molecule in      Ajay_Bhalla_2007_ReacDiff2 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 686    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 692    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 699    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 704    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 710    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 716    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 722    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 728    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 734    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 740    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 746    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 752    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 758    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 764    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 770    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 776    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 782    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 788    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 794    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 800    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 806    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 812    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 818    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 824    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 830    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 836    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 842    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 848    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 854    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 860    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 866    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 872    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 878    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 884    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 890    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 896    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 902    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 908    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 679    		01.5Yes
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 914    		01.5Yes
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992

    MAPKK* acting as an Enzyme in      Ajay_Bhalla_2007_ReacDiff2 Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 679    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    2MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 679    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    3MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 686    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    4MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 686    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    5MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 692    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    6MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 692    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    7MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 699    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    8MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 699    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    9MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 704    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    10MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 704    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    11MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 710    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    12MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 710    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    13MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 716    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    14MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 716    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    15MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 722    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    16MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 722    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    17MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 728    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    18MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 728    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    19MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 734    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    20MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 734    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    21MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 740    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    22MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 740    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    23MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 746    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    24MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 746    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    25MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 752    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    26MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 752    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    27MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 758    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    28MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 758    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    29MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 764    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    30MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 764    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    31MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 770    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    32MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 770    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    33MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 776    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    34MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 776    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    35MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 782    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    36MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 782    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    37MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 788    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    38MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 788    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    39MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 794    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    40MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 794    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    41MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 800    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    42MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 800    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    43MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 806    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    44MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 806    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    45MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 812    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    46MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 812    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    47MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 818    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    48MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 818    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    49MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 824    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    50MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 824    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    51MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 830    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    52MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 830    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    53MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 836    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    54MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 836    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    55MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 842    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    56MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 842    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    57MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 848    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    58MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 848    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    59MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 854    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    60MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 854    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    61MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 860    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    62MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 860    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    63MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 866    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    64MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 866    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    65MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 872    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    66MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 872    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    67MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 878    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    68MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 878    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    69MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 884    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    70MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 884    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    71MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 890    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    72MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 890    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    73MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 896    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    74MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 896    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    75MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 902    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    76MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 902    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    77MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 908    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    78MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 908    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    79MAPKK* /
    MAPKKtyr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 914    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    80MAPKK* /
    MAPKKthr
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 914    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.

    MAPKK* acting as a Substrate for an Enzyme in      Ajay_Bhalla_2007_ReacDiff2 Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    2PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics
    Pathway No. : 684    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    3PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[1]
    Pathway No. : 690    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    4PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[2]
    Pathway No. : 697    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    5PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[3]
    Pathway No. : 694    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    6PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[4]
    Pathway No. : 708    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    7PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[5]
    Pathway No. : 714    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    8PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[6]
    Pathway No. : 720    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    9PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[7]
    Pathway No. : 726    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    10PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[8]
    Pathway No. : 732    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    11PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[9]
    Pathway No. : 738    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    12PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[10]
    Pathway No. : 744    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    13PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[11]
    Pathway No. : 750    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    14PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[12]
    Pathway No. : 756    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    15PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[13]
    Pathway No. : 762    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    16PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[14]
    Pathway No. : 768    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    17PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[15]
    Pathway No. : 774    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    18PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[16]
    Pathway No. : 780    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    19PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[17]
    Pathway No. : 786    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    20PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[18]
    Pathway No. : 792    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    21PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[19]
    Pathway No. : 798    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    22PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[20]
    Pathway No. : 804    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    23PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[21]
    Pathway No. : 810    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    24PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[22]
    Pathway No. : 816    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    25PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[23]
    Pathway No. : 822    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    26PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[24]
    Pathway No. : 828    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    27PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[25]
    Pathway No. : 834    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    28PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[26]
    Pathway No. : 840    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    29PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[27]
    Pathway No. : 846    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    30PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[28]
    Pathway No. : 852    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    31PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[29]
    Pathway No. : 858    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    32PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[30]
    Pathway No. : 864    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    33PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[31]
    Pathway No. : 870    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    34PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[32]
    Pathway No. : 876    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    35PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[33]
    Pathway No. : 882    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    36PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[34]
    Pathway No. : 888    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    37PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[35]
    Pathway No. : 894    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    38PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[36]
    Pathway No. : 900    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    39PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[37]
    Pathway No. : 906    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    40PPhosphatase2A  /
    MAPKK-deph
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[38]
    Pathway No. : 912    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.

    MAPKK* acting as a Product of an Enzyme in      Ajay_Bhalla_2007_ReacDiff2 Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 679    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    2Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 679    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    3Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 686    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    4Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 686    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    5Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 692    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    6Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 692    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    7Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 699    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    8Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 699    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    9Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 704    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    10Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 704    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    11Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 710    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    12Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 710    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    13Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 716    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    14Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 716    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    15Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 722    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    16Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 722    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    17Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 728    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    18Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 728    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    19Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 734    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    20Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 734    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    21Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 740    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    22Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 740    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    23Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 746    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    24Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 746    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    25Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 752    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    26Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 752    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    27Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 758    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    28Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 758    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    29Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 764    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    30Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 764    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    31Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 770    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    32Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 770    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    33Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 776    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    34Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 776    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    35Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 782    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    36Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 782    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    37Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 788    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    38Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 788    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    39Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 794    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    40Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 794    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    41Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 800    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    42Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 800    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    43Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 806    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    44Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 806    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    45Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 812    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    46Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 812    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    47Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 818    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    48Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 818    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    49Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 824    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    50Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 824    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    51Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 830    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    52Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 830    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    53Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 836    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    54Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 836    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    55Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 842    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    56Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 842    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    57Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 848    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    58Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 848    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    59Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 854    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    60Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 854    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    61Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 860    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    62Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 860    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    63Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 866    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    64Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 866    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    65Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 872    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    66Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 872    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    67Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 878    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    68Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 878    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    69Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 884    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    70Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 884    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    71Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 890    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    72Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 890    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    73Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 896    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    74Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 896    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    75Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 902    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    76Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 902    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    77Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 908    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    78Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 908    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    79Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 914    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    80Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• MAPK
    Pathway No. : 914    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6

    MAPKK* acting as a Substrate in a reaction in      Ajay_Bhalla_2007_ReacDiff2 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    25diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    26diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    27diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    28diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    29diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    30diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    31diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    32diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    33diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    34diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    35diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    37diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    39diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*

    MAPKK* acting as a Product in a reaction in      Ajay_Bhalla_2007_ReacDiff2 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    25diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    26diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    27diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    28diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    29diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    30diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    31diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    32diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    33diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    34diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    35diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    37diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*
    39diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    MAPKK*

    Product
    MAPKK*


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.