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Molecule Parameter List for PKC-DAG

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-DAG participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences4000003979

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff2
    		• 83NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff,  PKC,  MAPK,  
    Ras,  CaM,  PKM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[1],  
    PKC,  MAPK,  Ras,  kinetics[3],  CaM,  PKM,  kinetics[2],  PKC,  MAPK,  Ras,  
    CaM,  PKM,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[4],  PKC,  MAPK,  Ras,  CaM,  
    PKM,  kinetics[5],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[6],  PKC,  MAPK,  
    Ras,  CaM,  PKM,  kinetics[7],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[8],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[9],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[10],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[11],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[12],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[13],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[14],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[15],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[16],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[17],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[18],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[19],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[20],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[21],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[22],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[23],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[24],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[25],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[26],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[27],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[28],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[29],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[30],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[31],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[32],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[33],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[34],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[35],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[36],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[37],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[38],  
    PKC,  MAPK,  Ras,  CaM,  PKM 
    This is a 40-compartment reaction-diffusion-transport version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 40 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec In addition, we have a forward (dendrite to soma) transport term of 1 microns/sec. This converts to a rate of 0.1/sec, but applies only to the kf. So the total kf of the diffusion 'reaction' is 0.11 for D = 1 micron^2/sec, and kb is 0.01. If D=0.1 micron^2/sec then kf = 0.101 and kb = 0.001. In addition this model has all molecules buffered in the first and last compartments. This boundary conditions says that the molecules are not drained out of the first compartment, nor do they all pile up in the last one.
    The stimulus file pkm_mapk22_transp_endbuf_D1e-13_Fig4CD which was used for the model to replicate Figure 4C and 4D from the paper.

    PKC-DAG acting as a Molecule in      Ajay_Bhalla_2007_ReacDiff2 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 685    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 691    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 698    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 703    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 709    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 715    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 721    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 775    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 727    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 733    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 739    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 745    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 751    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 757    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 763    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 769    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 871    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 781    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 787    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 793    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 799    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 805    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 811    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 817    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 823    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 829    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 835    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 841    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 847    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 853    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 859    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 865    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 877    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 883    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 889    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 895    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 901    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 907    		0.06021.5No
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 678    		0.06021.5Yes
    CoInit was .0624
    PKC-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 913    		0.06021.5Yes
    CoInit was .0624

    PKC-DAG acting as a Substrate in a reaction in      Ajay_Bhalla_2007_ReacDiff2 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    25diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    26diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    27diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    28diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    29diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    30diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    31diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    32diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    33diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    34diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    35diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    37diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    39diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG

    PKC-DAG acting as a Product in a reaction in      Ajay_Bhalla_2007_ReacDiff2 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 678    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    3PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 685    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    5PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 691    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    7PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 698    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    9PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 703    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    11PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 709    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    13PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 715    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    15PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 721    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    17PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 775    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    18PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 727    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    20PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 733    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    22PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 739    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    24PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 745    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    25diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    26PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 751    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    27diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    28PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 757    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    29diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    30PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 763    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    31diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    32PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 769    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    33diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    34PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 871    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    35diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    37PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 781    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    39PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 787    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    40diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    41PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 793    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    42diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    43PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 799    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    44diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    45PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 805    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    46diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    47PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 811    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    48diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    49PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 817    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    50diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    51PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 823    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    52diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    53PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 829    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    54diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    55PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 835    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    56diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    57PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 841    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    58diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    59PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 847    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    60diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    61PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 853    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    62diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    63PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 859    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    64diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    65PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 865    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    66diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    67PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 877    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    68diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    69PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 883    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    70diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    71PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 889    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    72diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    73PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 895    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    74diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    75PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 901    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    76diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    77PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 907    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    78diff
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 0.101
    (s^-1)    		0.001
    (s^-1)    		Keq = 0.0099(uM)9.804secSubstrate
    PKC-DAG

    Product
    PKC-DAG
    79PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 913    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9


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