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Molecule Parameter List for GTP | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| GTP participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | CondorelliGC | 19 | Pathway |
condorelliGCmod | | This model features the observations of Condorelli P, George SC. Biophys J. (2001) 80(5):2110-9. They propose a in vivo mechanism for the binding of free NO to sGC based on in vitro data within both pulmonary and vascular smooth muscle. All the parameters used have been obtained from reported results based on experiments. One important conclusion they make is that control of sGC in vivo is most likely to be ultra-sensitive and that activation in vivo occurs at lower NO concentrations than previously reported. |
GTP acting as a Molecule in CondorelliGC Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | GTP | CondorelliGC
Accession No. : 19 | condorelliGCmod
Pathway No. : 89 | 1000 | 0.0016667 | No | | Under in vivo conditions, GTP is present in excess, ~ 1 mM. |
GTP acting as a Substrate for an Enzyme in CondorelliGC Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | NO_sGCfull_act /
full_act_sGC | CondorelliGC
Accession No. : 19 | condorelliGCmod
Pathway No. : 89 | 57.9996 | 40 | 4 | explicit E-S complex | Substrate
GTP
Product
cGMP
| | Km values for the basal and fully activated forms of sGC have been determined as 85-120 uM and 58 uM, respectively ... (Ignarro et al., 1982, BBA, 718:49-59)..and the same has been used by Condorelli et al., 2001... Vmax values are around 10-100 nmol/min/mg (without NO) and 10-40 umol/min/mg (with NO) ..... thru personal correspondence with T Bellamy, UK. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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