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Molecule Parameter List for MAPKK-ser

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*MAPKK-ser* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	40	0	0	120	120	39	39

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_Bhalla_ 2007_ReacDiff2	83	Network	Shared_Object_Ajay_Bhalla_2007_ReacDiff, PKC, MAPK, Ras, CaM, PKM, chain, kinetics, PKC, MAPK, Ras, CaM, PKM, kinetics[1], PKC, MAPK, Ras, kinetics[3], CaM, PKM, kinetics[2], PKC, MAPK, Ras, CaM, PKM, PKC, MAPK, Ras, CaM, PKM, kinetics[4], PKC, MAPK, Ras, CaM, PKM, kinetics[5], PKC, MAPK, Ras, CaM, PKM, kinetics[6], PKC, MAPK, Ras, CaM, PKM, kinetics[7], PKC, MAPK, Ras, CaM, PKM, kinetics[8], PKC, MAPK, Ras, CaM, PKM, kinetics[9], PKC, MAPK, Ras, CaM, PKM, kinetics[10], PKC, MAPK, Ras, CaM, PKM, kinetics[11], PKC, MAPK, Ras, CaM, PKM, kinetics[12], PKC, MAPK, Ras, CaM, PKM, kinetics[13], PKC, MAPK, Ras, CaM, PKM, kinetics[14], PKC, MAPK, Ras, CaM, PKM, kinetics[15], PKC, MAPK, Ras, CaM, PKM, kinetics[16], PKC, MAPK, Ras, CaM, PKM, kinetics[17], PKC, MAPK, Ras, CaM, PKM, kinetics[18], PKC, MAPK, Ras, CaM, PKM, kinetics[19], PKC, MAPK, Ras, CaM, PKM, kinetics[20], PKC, MAPK, Ras, CaM, PKM, kinetics[21], PKC, MAPK, Ras, CaM, PKM, kinetics[22], PKC, MAPK, Ras, CaM, PKM, kinetics[23], PKC, MAPK, Ras, CaM, PKM, kinetics[24], PKC, MAPK, Ras, CaM, PKM, kinetics[25], PKC, MAPK, Ras, CaM, PKM, kinetics[26], PKC, MAPK, Ras, CaM, PKM, kinetics[27], PKC, MAPK, Ras, CaM, PKM, kinetics[28], PKC, MAPK, Ras, CaM, PKM, kinetics[29], PKC, MAPK, Ras, CaM, PKM, kinetics[30], PKC, MAPK, Ras, CaM, PKM, kinetics[31], PKC, MAPK, Ras, CaM, PKM, kinetics[32], PKC, MAPK, Ras, CaM, PKM, kinetics[33], PKC, MAPK, Ras, CaM, PKM, kinetics[34], PKC, MAPK, Ras, CaM, PKM, kinetics[35], PKC, MAPK, Ras, CaM, PKM, kinetics[36], PKC, MAPK, Ras, CaM, PKM, kinetics[37], PKC, MAPK, Ras, CaM, PKM, kinetics[38], PKC, MAPK, Ras, CaM, PKM
This is a 40-compartment reaction-diffusion-transport version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 40 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec In addition, we have a forward (dendrite to soma) transport term of 1 microns/sec. This converts to a rate of 0.1/sec, but applies only to the kf. So the total kf of the diffusion 'reaction' is 0.11 for D = 1 micron^2/sec, and kb is 0.01. If D=0.1 micron^2/sec then kf = 0.101 and kb = 0.001. In addition this model has all molecules buffered in the first and last compartments. This boundary conditions says that the molecules are not drained out of the first compartment, nor do they all pile up in the last one. The stimulus file pkm_mapk22_transp_endbuf_D1e-13_Fig4CD which was used for the model to replicate Figure 4C and 4D from the paper.

MAPKK-ser acting as a Molecule in Ajay_Bhalla_2007_ReacDiff2 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 686	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 692	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 699	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 704	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 710	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 716	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 722	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 728	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 734	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 740	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 746	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 752	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 758	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 764	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 770	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 776	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 782	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 788	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 794	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 800	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 806	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 812	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 818	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 824	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 830	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 836	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 842	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 848	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 854	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 860	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 866	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 872	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 878	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 884	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 890	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 896	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 902	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 908	0.002	1.5	No
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 679	0.002	1.5	Yes
Intermediately phophorylated, assumed inactive, form of MAPKK
MAPKK-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 914	0.002	1.5	Yes
Intermediately phophorylated, assumed inactive, form of MAPKK

MAPKK-ser acting as a Substrate for an Enzyme in Ajay_Bhalla_2007_ReacDiff2 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 679	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
2	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 679	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
3	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

4	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 686	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
5	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 686	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
6	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics Pathway No. : 684	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

7	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 692	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
8	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 692	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
9	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[1] Pathway No. : 690	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

10	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 699	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
11	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 699	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
12	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[2] Pathway No. : 697	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

13	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 704	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
14	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 704	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
15	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[3] Pathway No. : 694	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

16	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 710	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
17	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 710	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
18	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[4] Pathway No. : 708	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

19	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 716	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
20	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 716	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
21	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[5] Pathway No. : 714	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

22	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 722	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
23	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 722	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
24	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[6] Pathway No. : 720	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

25	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 728	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
26	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 728	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
27	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[7] Pathway No. : 726	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

28	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 734	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
29	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 734	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
30	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[8] Pathway No. : 732	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

31	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 740	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
32	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 740	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
33	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[9] Pathway No. : 738	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

34	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 746	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
35	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 746	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
36	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[10] Pathway No. : 744	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

37	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 752	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
38	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 752	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
39	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[11] Pathway No. : 750	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

40	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 758	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
41	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 758	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
42	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[12] Pathway No. : 756	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

43	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 764	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
44	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 764	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
45	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[13] Pathway No. : 762	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

46	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 770	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
47	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 770	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
48	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[14] Pathway No. : 768	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

49	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 776	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
50	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 776	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
51	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[15] Pathway No. : 774	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

52	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 782	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
53	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 782	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
54	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[16] Pathway No. : 780	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

55	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 788	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
56	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 788	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
57	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[17] Pathway No. : 786	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

58	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 794	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
59	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 794	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
60	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[18] Pathway No. : 792	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

61	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 800	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
62	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 800	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
63	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[19] Pathway No. : 798	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

64	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 806	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
65	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 806	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
66	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[20] Pathway No. : 804	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

67	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 812	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
68	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 812	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
69	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[21] Pathway No. : 810	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

70	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 818	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
71	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 818	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
72	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[22] Pathway No. : 816	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

73	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 824	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
74	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 824	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
75	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[23] Pathway No. : 822	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

76	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 830	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
77	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 830	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
78	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[24] Pathway No. : 828	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

79	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 836	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
80	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 836	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
81	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[25] Pathway No. : 834	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

82	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 842	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
83	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 842	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
84	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[26] Pathway No. : 840	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

85	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 848	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
86	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 848	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
87	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[27] Pathway No. : 846	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

88	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 854	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
89	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 854	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
90	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[28] Pathway No. : 852	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

91	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 860	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
92	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 860	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
93	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[29] Pathway No. : 858	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

94	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 866	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
95	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 866	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
96	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[30] Pathway No. : 864	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

97	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 872	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
98	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 872	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
99	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[31] Pathway No. : 870	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

100	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 878	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
101	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 878	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
102	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[32] Pathway No. : 876	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

103	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 884	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
104	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 884	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
105	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[33] Pathway No. : 882	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

106	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 890	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
107	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 890	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
108	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[34] Pathway No. : 888	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

109	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 896	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
110	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 896	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
111	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[35] Pathway No. : 894	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

112	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 902	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
113	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 902	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
114	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[36] Pathway No. : 900	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

115	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 908	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
116	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 908	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
117	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[37] Pathway No. : 906	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

118	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 914	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
119	Raf-GTP-Ras / Raf-GTP-Ras.2	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 914	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*
	Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
120	PPhosphatase2A / MAPKK-deph-ser	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[38] Pathway No. : 912	15.6567	6	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK

MAPKK-ser acting as a Product of an Enzyme in Ajay_Bhalla_2007_ReacDiff2 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 679	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
2	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 679	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
3	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
4	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 686	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
5	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 686	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
6	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics Pathway No. : 684	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
7	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 692	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
8	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 692	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
9	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[1] Pathway No. : 690	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
10	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 699	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
11	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 699	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
12	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[2] Pathway No. : 697	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
13	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 704	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
14	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 704	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
15	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[3] Pathway No. : 694	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
16	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 710	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
17	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 710	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
18	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[4] Pathway No. : 708	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
19	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 716	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
20	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 716	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
21	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[5] Pathway No. : 714	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
22	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 722	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
23	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 722	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
24	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[6] Pathway No. : 720	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
25	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 728	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
26	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 728	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
27	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[7] Pathway No. : 726	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
28	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 734	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
29	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 734	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
30	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[8] Pathway No. : 732	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
31	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 740	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
32	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 740	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
33	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[9] Pathway No. : 738	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
34	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 746	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
35	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 746	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
36	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[10] Pathway No. : 744	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
37	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 752	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
38	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 752	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
39	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[11] Pathway No. : 750	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
40	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 758	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
41	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 758	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
42	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[12] Pathway No. : 756	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
43	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 764	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
44	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 764	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
45	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[13] Pathway No. : 762	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
46	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 770	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
47	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 770	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
48	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[14] Pathway No. : 768	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
49	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 776	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
50	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 776	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
51	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[15] Pathway No. : 774	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
52	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 782	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
53	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 782	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
54	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[16] Pathway No. : 780	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
55	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 788	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
56	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 788	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
57	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[17] Pathway No. : 786	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
58	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 794	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
59	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 794	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
60	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[18] Pathway No. : 792	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
61	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 800	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
62	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 800	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
63	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[19] Pathway No. : 798	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
64	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 806	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
65	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 806	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
66	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[20] Pathway No. : 804	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
67	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 812	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
68	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 812	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
69	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[21] Pathway No. : 810	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
70	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 818	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
71	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 818	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
72	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[22] Pathway No. : 816	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
73	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 824	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
74	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 824	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
75	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[23] Pathway No. : 822	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
76	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 830	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
77	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 830	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
78	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[24] Pathway No. : 828	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
79	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 836	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
80	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 836	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
81	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[25] Pathway No. : 834	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
82	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 842	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
83	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 842	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
84	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[26] Pathway No. : 840	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
85	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 848	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
86	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 848	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
87	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[27] Pathway No. : 846	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
88	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 854	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
89	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 854	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
90	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[28] Pathway No. : 852	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
91	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 860	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
92	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 860	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
93	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[29] Pathway No. : 858	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
94	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 866	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
95	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 866	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
96	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[30] Pathway No. : 864	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
97	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 872	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
98	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 872	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
99	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[31] Pathway No. : 870	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
100	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 878	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
101	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 878	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
102	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[32] Pathway No. : 876	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
103	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 884	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
104	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 884	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
105	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[33] Pathway No. : 882	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
106	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 890	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
107	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 890	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
108	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[34] Pathway No. : 888	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
109	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 896	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
110	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 896	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
111	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[35] Pathway No. : 894	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
112	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 902	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
113	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 902	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
114	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[36] Pathway No. : 900	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
115	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 908	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
116	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 908	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
117	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[37] Pathway No. : 906	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
118	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 914	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
119	Raf-GTP-Ras / Raf-GTP-Ras.1	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	MAPK Pathway No. : 914	0.159096	0.3	4	explicit E-S complex	Substrate MAPKK Product MAPKK-ser
	Kinetics are the same as for the craf-1* activity, ie., k1=1.1e-6, k2=.42, k3 =0.105 These are based on Force et al PNAS USA 91 1270-1274 1994. These parms cannot reach the observed 4X stim of MAPK. So lets increase the affinity, ie, raise k1 10X to 1.1e-5 Lets take it back down to where it was. Back up to 5X: 5.5e-6
120	PPhosphatase2A / MAPKK-deph	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	kinetics[38] Pathway No. : 912	15.6567	6	4	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.

MAPKK-ser acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff2 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
2	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
3	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
4	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
5	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
6	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
7	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
8	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
9	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
10	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
11	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
12	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
13	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
14	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
15	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
16	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
17	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
18	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
19	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
20	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
21	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
22	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
23	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
24	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
25	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
26	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
27	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
28	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
29	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
30	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
31	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
32	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
33	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
34	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
35	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
36	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
37	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
38	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
39	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser

MAPKK-ser acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff2 Network

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
2	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
3	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
4	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
5	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
6	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
7	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
8	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
9	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
10	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
11	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
12	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
13	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
14	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
15	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
16	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
17	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
18	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
19	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
20	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
21	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
22	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
23	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
24	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
25	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
26	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
27	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
28	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
29	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
30	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
31	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
32	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
33	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
34	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
35	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
36	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
37	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
38	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser
39	diff	Ajay_Bhalla_ 2007_ReacDiff2 Accession No. : 83	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff Pathway No. : 677	0.101 (s^-1)	0.001 (s^-1)	Keq = 0.0099(uM)	9.804sec	Substrate MAPKK-ser Product MAPKK-ser

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