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Molecule Parameter List for CaM-GEF

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaM-GEF participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences40040003979

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff2
  • 83NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff PKC MAPK 
    Ras CaM PKM chain kinetics PKC MAPK Ras CaM PKM kinetics[1] 
    PKC MAPK Ras kinetics[3] CaM PKM kinetics[2] PKC MAPK Ras 
    CaM PKM PKC MAPK Ras CaM PKM kinetics[4] PKC MAPK Ras CaM 
    PKM kinetics[5] PKC MAPK Ras CaM PKM kinetics[6] PKC MAPK 
    Ras CaM PKM kinetics[7] PKC MAPK Ras CaM PKM kinetics[8] 
    PKC MAPK Ras CaM PKM kinetics[9] PKC MAPK Ras CaM PKM kinetics[10] 
    PKC MAPK Ras CaM PKM kinetics[11] PKC MAPK Ras CaM PKM kinetics[12] 
    PKC MAPK Ras CaM PKM kinetics[13] PKC MAPK Ras CaM PKM kinetics[14] 
    PKC MAPK Ras CaM PKM kinetics[15] PKC MAPK Ras CaM PKM kinetics[16] 
    PKC MAPK Ras CaM PKM kinetics[17] PKC MAPK Ras CaM PKM kinetics[18] 
    PKC MAPK Ras CaM PKM kinetics[19] PKC MAPK Ras CaM PKM kinetics[20] 
    PKC MAPK Ras CaM PKM kinetics[21] PKC MAPK Ras CaM PKM kinetics[22] 
    PKC MAPK Ras CaM PKM kinetics[23] PKC MAPK Ras CaM PKM kinetics[24] 
    PKC MAPK Ras CaM PKM kinetics[25] PKC MAPK Ras CaM PKM kinetics[26] 
    PKC MAPK Ras CaM PKM kinetics[27] PKC MAPK Ras CaM PKM kinetics[28] 
    PKC MAPK Ras CaM PKM kinetics[29] PKC MAPK Ras CaM PKM kinetics[30] 
    PKC MAPK Ras CaM PKM kinetics[31] PKC MAPK Ras CaM PKM kinetics[32] 
    PKC MAPK Ras CaM PKM kinetics[33] PKC MAPK Ras CaM PKM kinetics[34] 
    PKC MAPK Ras CaM PKM kinetics[35] PKC MAPK Ras CaM PKM kinetics[36] 
    PKC MAPK Ras CaM PKM kinetics[37] PKC MAPK Ras CaM PKM kinetics[38] 
    PKC MAPK Ras CaM PKM 
    This is a 40-compartment reaction-diffusion-transport version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 40 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec In addition, we have a forward (dendrite to soma) transport term of 1 microns/sec. This converts to a rate of 0.1/sec, but applies only to the kf. So the total kf of the diffusion 'reaction' is 0.11 for D = 1 micron^2/sec, and kb is 0.01. If D=0.1 micron^2/sec then kf = 0.101 and kb = 0.001. In addition this model has all molecules buffered in the first and last compartments. This boundary conditions says that the molecules are not drained out of the first compartment, nor do they all pile up in the last one.
    The stimulus file pkm_mapk22_transp_endbuf_D1e-13_Fig4CD which was used for the model to replicate Figure 4C and 4D from the paper.

    CaM-GEF acting as a Molecule in  
    Ajay_Bhalla_2007_ReacDiff2 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 687
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 693
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 700
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 705
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 711
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 717
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 723
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 729
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 735
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 741
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 747
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 753
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 759
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 765
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 771
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 777
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 783
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 789
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 795
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 801
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 807
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 813
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 819
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 825
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 831
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 837
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 843
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 849
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 855
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 861
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 867
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 873
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 879
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 885
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 891
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 897
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 903
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 909
    0.00021.5No
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 680
    0.00021.5Yes
    See Farnsworth et al Nature 376 524-527 1995
    CaM-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 915
    0.00021.5Yes
    See Farnsworth et al Nature 376 524-527 1995

    CaM-GEF acting as an Enzyme in  
    Ajay_Bhalla_2007_ReacDiff2 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 680
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    2CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 687
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    3CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 693
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    4CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 700
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    5CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 705
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    6CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 711
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    7CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 717
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    8CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 723
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    9CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 729
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    10CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 735
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    11CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 741
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    12CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 747
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    13CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 753
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    14CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 759
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    15CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 765
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    16CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 771
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    17CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 777
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    18CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 783
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    19CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 789
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    20CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 795
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    21CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 801
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    22CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 807
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    23CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 813
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    24CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 819
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    25CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 825
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    26CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 831
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    27CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 837
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    28CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 843
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    29CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 849
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    30CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 855
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    31CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 861
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    32CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 867
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    33CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 873
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    34CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 879
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    35CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 885
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    36CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 891
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    37CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 897
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    38CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 903
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    39CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 909
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.
    40CaM-GEF /
    CaM-GEF-act-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 915
    0.5050570.24explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras
        Kinetics same as GEF-bg_act-ras, but as of March 17, 2006, the kcat is scaled from 0.02 to 0.2 to have a stronger Ca response for the direct MAPK input.

    CaM-GEF acting as a Substrate in a reaction in  
    Ajay_Bhalla_2007_ReacDiff2 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    25diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    26diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    27diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    28diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    29diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    30diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    31diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    32diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    33diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    34diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    35diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    37diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    39diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF

    CaM-GEF acting as a Product in a reaction in  
    Ajay_Bhalla_2007_ReacDiff2 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 680
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    3CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 687
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    5CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 693
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    7CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 700
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    9CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 705
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    11CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 711
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    13CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 717
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    15CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 723
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    17CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 729
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    19CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 735
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    21CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 741
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    23CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 747
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    25CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 753
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    26diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    27CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 759
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    28diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    29CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 765
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    30diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    31CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 771
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    32diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    33CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 777
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    34diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    35CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 783
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    37CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 789
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    39CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 795
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    40diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    41CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 801
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    42diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    43CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 807
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    44diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    45CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 813
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    46diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    47CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 819
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    48diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    49CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 825
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    50diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    51CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 831
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    52diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    53CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 837
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    54diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    55CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 843
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    56diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    57CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 849
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    58diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    59CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 855
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    60diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    61CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 861
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    62diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    63CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 867
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    64diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    65CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 873
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    66diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    67CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 879
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    68diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    69CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 885
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    70diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    71CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 891
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    72diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    73CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 897
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    74diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    75CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 903
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    76diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    77CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 909
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
    78diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    CaM-GEF

    Product
    CaM-GEF
    79CaM-bind-GEF
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 915
    199.995
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    CaM-Ca4
    inact-GEF

    Product
    CaM-GEF
      We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995



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