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Molecule Parameter List for IE

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IE participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Mammalian_cell_
    cycle
  • 85Network
    Growth CELLDIV Rb_grp 
    IE_GRP CycB_Grp Cdc20_Grp 
    Cdh1_grp E2F CycA_Grp 
    CycE_grp Early_Response_Genes Delayed_Response_Genes 
    CycD_Grp 
    This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules.

    IE acting as a Molecule in  
    Mammalian_cell_cycle Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IE
  • Mammalian_cell_
    cycle

    Accession No. : 85
  • IE_GRP
    Pathway No. : 1072
    1200No
    According to the paper: IE is an intermediary enzyme that creates a time delay between CycB accumulation and Cdc20 activation. No initial value for this is given. I assume it is 1.

    IE acting as a Substrate for an Enzyme in  
    Mammalian_cell_cycle Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    CycB  /
    k31
  • Mammalian_cell_
    cycle

    Accession No. : 85
  • CELLDIV
    Pathway No. : 1070
    0.009999890.74explicit E-S complexSubstrate
    IE

    Product
    IEP
    Represented as k31.[IE].[CycB]/(J31 + [IE]) k31 = 0.7 J31 = 0.01

    IE acting as a Product of an Enzyme in  
    Mammalian_cell_cycle Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PPX  /
    k32
  • Mammalian_cell_
    cycle

    Accession No. : 85
  • IE_GRP
    Pathway No. : 1072
    0.011.84explicit E-S complexSubstrate
    IEP

    Product
    IE
    Represented as k32.[PPx].[IEP] / (J32 + [IEP]) k32 = 1.8 J32 = 0.01



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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