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Molecule Parameter List for DRG_synth

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
DRG_synth participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Mammalian_cell_
    cycle
  • 85Network
    Growth CELLDIV Rb_grp 
    IE_GRP CycB_Grp Cdc20_Grp 
    Cdh1_grp E2F CycA_Grp 
    CycE_grp Early_Response_Genes Delayed_Response_Genes 
    CycD_Grp 
    This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules.

    DRG_synth acting as a Molecule in  
    Mammalian_cell_cycle Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    DRG_synth
  • Mammalian_cell_
    cycle

    Accession No. : 85
  • Delayed_
    Response_Genes

    Pathway No. : 1080
  • 1200Yes
    Enzyme that synthesiszes ERG. Enters into equations only implicitly. Initial conc set to 1.

    DRG_synth acting as an Enzyme in  
    Mammalian_cell_cycle Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    DRG_synth /
    DRG_synth
  • Mammalian_cell_
    cycle

    Accession No. : 85
  • Delayed_
    Response_Genes

    Pathway No. : 1080
  • 0.0899986104explicit E-S complexSubstrate
    DRG_2A

    Product
    DRG
    k17 = 10 J17 = 0.3 This enz represents rate = k17([DRG]/J17)^2 / (1 + ([DRG]/J17)^2 ) Here we assume that the substrate conc = [DRG]^2. Then it expands into classical MM form: rate = k17.sub / (J17^2 + sub) provided [DRG_synth] = 1.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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