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Molecule Parameter List for Heaviside_dup

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Heaviside_dup participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1101000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Mammalian_cell_
    cycle
  • 85Network
    Growth CELLDIV Rb_grp 
    IE_GRP CycB_Grp Cdc20_Grp 
    Cdh1_grp E2F CycA_Grp 
    CycE_grp Early_Response_Genes Delayed_Response_Genes 
    CycD_Grp 
    This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules.

    Heaviside_dup acting as a Molecule in  
    Mammalian_cell_cycle Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    Heaviside_dup
  • Mammalian_cell_
    cycle

    Accession No. : 85
  • Growth
    Pathway No. : 1069
    0200No

    Heaviside_dup acting as a Summed Molecule in  
    Mammalian_cell_cycle Network
    Accession NamePathway NameTargetInput
  • Mammalian_cell_
    cycle

    Accession No. : 85
  • Growth
    Pathway No. : 1069
    Heaviside_dupHeaviside_inh

    Heaviside_dup acting as a Substrate for an Enzyme in  
    Mammalian_cell_cycle Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    mass  /
    k27
  • Mammalian_cell_
    cycle

    Accession No. : 85
  • Growth
    Pathway No. : 1069
    1024explicit E-S complexSubstrate
    Heaviside_dup

    Product
    GM
    Equation 17 dGM/dt = k27 * mass * Heaviside_out. k27 = 0.2 If k3 << k2, we have ES ~ E.S.k1/k2 and rate = k3 * ES. So we assume k2 = 1, k3 = 0.1, then k1 = 10 * k27 so k1 = 2. This gives a rather low Km, leading to much complex formation. Let us use MM form, and assume Km >> Heaviside_out. Take Km = 10, then kcat = Km * k27 = 2



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