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Molecule Parameter List for PIP3_AKT_thr308

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*PIP3_AKT_thr308* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	2	2	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AKT	87	Network	Shared_Object_AKT, AKT_mod
This is one of the sub-model of BDNF signaling cascade. PIP3 activies AKT, leading to accumulation of Rheb-GTP, a regulator of mTOR.

PIP3_AKT_thr308 acting as a Molecule in AKT Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PIP3_AKT_thr308	AKT Accession No. : 87	AKT_mod Pathway No. : 1086	0	999.97	No

PIP3_AKT_thr308 acting as a Substrate for an Enzyme in AKT Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PIP3_PDK2 / phosp_AKTser473	AKT Accession No. : 87	AKT_mod Pathway No. : 1086	0.800013	20	4	explicit E-S complex	Substrate PIP3_AKT_thr308 Product PIP3_AKT-t308_ s473
2	PP2A / Dephosph_ AKTthr308	AKT Accession No. : 87	Shared_Object_ AKT Pathway No. : 1085	4.80015	1.8	4	explicit E-S complex	Substrate PIP3_AKT_thr308 Product PIP3_AKT

PIP3_AKT_thr308 acting as a Product of an Enzyme in AKT Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PIP3_PDK1 / phospho_thr308	AKT Accession No. : 87	AKT_mod Pathway No. : 1086	0.399987	10	4	explicit E-S complex	Substrate PIP3_AKT Product PIP3_AKT_thr308
2	PP2A / Dephos_ AKTser473	AKT Accession No. : 87	Shared_Object_ AKT Pathway No. : 1085	4.8	1.8	4	explicit E-S complex	Substrate PIP3_AKT-t308_ s473 Product PIP3_AKT_thr308

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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