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Molecule Parameter List for 4E-BP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
4E-BP participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001110

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
4EBP89Network
Shared_Object_4EBP mTOR_model 4E-BP_mod 
Rheb-GTP activates mTOR, again with regulation by MAPK, leading to formation of the eIF4F-mRNA complex.

4E-BP acting as a Molecule in  
4EBP Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
4E-BP4EBP
Accession No. : 89
4E-BP_mod
Pathway No. : 1092
01000No

4E-BP acting as a Substrate for an Enzyme in  
4EBP Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
  • TOR_Rheb-GTP_
    clx
      /
    TOR_4E-BP*
  • 4EBP
    Accession No. : 89
  • Shared_Object_
    4EBP

    Pathway No. : 1090
  • 1.8000114explicit E-S complexSubstrate
    4E-BP

    Product
    4E-BP_t37_46

    4E-BP acting as a Product of an Enzyme in  
    4EBP Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP2A  /
    PP2A_4E-BP*
    4EBP
    Accession No. : 89
  • Shared_Object_
    4EBP

    Pathway No. : 1090
  • 8.814explicit E-S complexSubstrate
    4E-BP_t37_46

    Product
    4E-BP

    4E-BP acting as a Substrate in a reaction in  
    4EBP Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    eIF4E_bind_BP24EBP
    Accession No. : 89
    4E-BP_mod
    Pathway No. : 1092
    49.999
    (uM^-1 s^-1)
    0.15
    (s^-1)
    Kd(bf) = 0.003(uM)-Substrate
    4E-BP
    eIF4E

    Product
    eIF4E-BP



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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